deoxyribonuclease II

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de·ox·y·ri·bo·nu·cle·ase II

, DNase II
an endonuclease that cleaves both strands of native DNA (as well as single-stranded DNA) to produce a mixture of oligodeoxynucleotides, each ending in a 3'-phosphate.
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The contents of apoptotic cells are rapidly ingested by professional phagocytes or neighboring cells through mechanisms that are not fully understood (4), and the DNA is consequently completely digested by DNase II in lysosomes (1).
An exciting new observation is that cell-free DNA itself may be directly implicated in the etiology of RA, as suggested by a recent study on DNase II knockout mice, in which the mice developed symmetrical, erosive polyarthritis (34).