deoxyribonuclease

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deoxyribonuclease

 (DNase) [de-ok″sĭ-ri″bo-nu´kle-ās]
an enzyme that catalyzes the hydrolysis (depolymerization) of deoxyribonucleic acid (DNA).

de·ox·y·ri·bo·nu·cle·ase (DNAse, DNAase, DNase),

(de-oks'ē-rī'bō-nū'klē-ās),
Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease.

deoxyribonuclease

/de·oxy·ri·bo·nu·cle·ase/ (DNase) (-ri″bo-noo´kle-ās) any nuclease catalyzing the cleavage of phosphate ester linkages in deoxyribonucleic acids (DNA); separated by whether they cleave internal bonds or bonds at termini.

deoxyribonuclease

(dē-ŏk′sē-rī′bō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
n.
DNase.

APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.

de·ox·y·ri·bo·nu·cle·ase

(DNase) (de-oks'ē-rī'bō-nū'klē-ās)
Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease

deoxyribonuclease

An enzyme that cuts DNA strands by breaking PHOSPHODIESTER BONDS.

deoxyribonuclease (DNAse)

see NUCLEASE.

deoxyribonuclease

an enzyme that catalyzes the hydrolysis (depolymerization) of deoxyribonucleic acid (DNA). Abbreviated DNase.
References in periodicals archive ?
Crystal found that twice-daily inhalations of the drug, called DNase I, improved the lung functions of all 16 of the adult subjects.
DNase I isn't the only compound that clears cellular debris.
It remains unclear whether simply giving DNase I to lupus patients will help.
By using genetically engineered mice to measure the effects of DNase I, Moroy and his colleagues have opened a new area of investigation, according to Hess.
We have reported the presence of high DNase I activity and its gene expression in the anterior lobe of the pituitary gland of both sexes and the abrupt increase in its gene expression at the onset of puberty (4).
Human DNase I was purified from urine as described previously (8).
An assay reagent set for DNase I activity was prepared in two steps: production of a gel plate for keeping the CAM wet, and preparation of CAM containing reaction buffer.
Purified human DNase I of known activity (1 [micro]L) was placed on the penciled spot on the CAM sheet with a Pipetman P2 micropipette (Gilson).
The SRED/CAM method is based on the fact that SG shows fluorescence only with unhydrolyzed DNA and not with DNA digested by DNase I (5, 6).
The within- and between-run imprecision studies were performed with the buffer described above and purified human DNase I at two selected concentrations (at the low and high ends of the assay).