DNMT3B


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DNMT3B

A gene on chromosome 20q11.2 that encodes a DNA methyltransferase thought to function in de novo methylation, rather than maintenance methylation. The protein localises to the cytoplasm and nucleus; its expression is developmentally regulated.

Molecular pathology
DNMT3B mutations cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
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Ampliqon Gene Primer Sequence length (bp) DNMT1 Forward 5'-GAAGGAGCCCGTGGATG-3' 233 Reverse 5'-GTTGATGTCTGCGTGGTAG-3' DNMT3A Forward 5-TACGCACCACCTCCAC-3' no Reverse 5'-AGATGTCCTCAATGTTCC-3' DNMT3B Forward 5-CGACCTCACAGACGACAC-3' 170 Reverse 5'-TTCCAAACTCCTTCCCATCC-3' HOTAIR Forward 5'-CCAAACAGAGTCCGTTCAGTG-3' no Reverse 5-TACACAAGTAGCAGGGAAAGG-3' GAPDH Forward 5-GTGAACCATGAGAAGTATGACAAC-3' 123 Reverse 5-CATGAGTCCTTCCACGATACC-3' MEG3 Forward 5'-CGGCTGAAGAACTGCGGATGG-3' 198 Reverse 5'-CGTGGCTGTCGAGGGATrTCG-3' p53 Forward 5-TCCTCAGCATCTTATCCGAGTG-3' 265 Reverse 5'-AGGACAGGCACAAACACGCACC-3' bp: base pair.
Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.
However, the gene expression of DNMT1 and DNMT3B was not significantly different between DES and vehicle groups in either week (Figure 5A).
The enzymatic machinery for DNA methylation is composed mainly of three DNMTs: DNMT1, DNMT3A, and DNMT3B (Bestor 1988).
DNMT3B rs2424913 (MAF = 5%) and rs2424932 (MAF = 6%) are both situated in introns.
The DirectHyb HumanHT-12 (HT-12) array (Illumina) included one DNMTI transcript and five DNMT3B transcripts [the gene has alternatively spliced transcripts (National Library of Medicine 2012b)].
This analysis was performed by modeling a cross-product term between genotype (for DNMT1 as an ordinal variable with three categories, and for DNMT3B dichotomized because few individuals were variant homozygotes) and lower-order terms for genotype and Inurinary cadmium concentrations.
Effect modification of DNMT1 and DNMT3B genotypes on the association between In-transformed cadmium concentrations in urine and for LINE
DNMT1 expression in blood was much higher than DNMT3B expression (Table 4).