DNMT3A

DNMT3A

A gene on chromosome 2p23 that encodes a DNA methyltransferase thought to function in de novo methylation, rather than maintenance methylation. The protein localises to the cytoplasm and nucleus; its expression is developmentally regulated.
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DNMT3A mutations were also common, especially in older patients.
Mutations in the DNMT3A Exon 23 Independently Predict Poor Outcome in Older Patients with Acute Myeloid Leukaemia: A SWOG report.
55,56) Based on a modified clustered regularly interspaced short palindromic repeats/CRISPR associated proteins (CRISPR/Cas) system, in which dCas9, a nuclease-deficient form of Cas9 (DNA-binding molecule), is fused with TET1 or DNMT3A and expressed together with guide RNAs, dCas9-TET1 or -DNMT3A achieves demethylation or methylation of targeted promoter regions, respectively.
Trovagene will use its PCM technology to profile other dominant AML markers, such as FLT3, DNMT3A, NRAS, and KIT, to identify and measure patient therapy response.
5'te, erkek germ hucrelerinde DNA metiltransferaz DNMT3A ve DNMT3B, ve kofaktor DNMT3L (DNA methyltransferase 3-like) aktivasyonu ile global de novo DNA metilasyon orani yaklasik %10'dan %50'ye kadar hizla yukselmektedir (11).
Memelilerde 4 farkli DNMT enzimi (DNMT1, DNMT3A, DNMT3B, DNMT3L) bilinmektedir ve kanser gelisiminde en onemli olani DNMT1'dir (13).
Testing for DNMT3A mutations in FLT3-ITD subgroup of AML patients at the point of diagnosis and post-chemotherapy could improve treatment and predict chances of relapse and survival rates respectively
FLT3 (fms-like tyrosine kinase 3) and DNMT3A (DNA methyltransferase) mutations were assessed using PCR-based methods in all AML patients, as previously described [22, 23].
Bioactive nutrients including curcumin offer great potential in altering DNA methylation status which is catalyzed via DNMT1, DNMT3A and 3B.
Although these enzymes place in the same category of enzymes and have second catalytic characteristics but may have different role in tumor development: DNMT3A deletion can stimulate and grow the tumor (Gao, 2011) in the other hand, DNMT3B deletion can stop tumor creation through the deployment and activation of tumor suppressor genes have got silent earlier (Nosho, 2009; Linhart, 2007).
La mayor parte de ellas se encontraron en tres genes: DNMT3A, TET2 y ASXL1.
The majority of mutations occurred in just three genes; DNMT3A, TET2, and ASXL1.