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Bioactive nutrients including curcumin offer great potential in altering DNA methylation status which is catalyzed via DNMT1, DNMT3A and 3B.
Although these enzymes place in the same category of enzymes and have second catalytic characteristics but may have different role in tumor development: DNMT3A deletion can stimulate and grow the tumor (Gao, 2011) in the other hand, DNMT3B deletion can stop tumor creation through the deployment and activation of tumor suppressor genes have got silent earlier (Nosho, 2009; Linhart, 2007).
The majority of mutations occurred in just three genes; DNMT3A, TET2, and ASXL1.
The majority of mutations occurred in just three genes: DNMT3A, TET2, and ASXL1.
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
The methylation at the 5'-methylcytosine is catalyzed by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B (Bestor 2000; Chen and Li 2004).
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
DNMT3A and DNMT3B are involved in de novo methylation.
The findings suggest that DNMT3A mutations could be a biologic marker for identifying patients at risk for poor outcomes.
The methylation of CpG sites within the human genome is catalyzed by four well-documented DNA methyltransferases (DNMTs) named DNMT1, DNMT2, DNMT3A and DNMT3B (28).
On the other hand, LINE-1 methylation levels were positively associated with toenail concentrations of iron and nickel, and with seven variants in DNMT3A, TCN2, AS3MT, SLC19A1, and MTHFS genes.
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
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