DNMT1

DNMT1

A gene on chromosome 19q13.2 that encodes a DNA (cytosine-5-)-methyltransferase 1, which methylates CpG residues and plays a critical role in establishing and regulating tissue-specific patterns of cytosine methylation.

Molecular pathology
Aberrant methylation patterns are associated with certain human tumours (e.g., breast carcinoma) and developmental
abnormalities.
References in periodicals archive ?
At the forthcoming 94th annual AACR meeting, MethylGene will be disclosing the role of the human DNA methyltransferase isoforms: DNMT1 and DNMT3a in tumor cell oncogenesis and cancer cell survival.
Hypomethylated states associated with cancer and other pathological conditions often are accompanied by a downregulation of the gene encoding DNMT1 (Hervouet et al.
Also presented were new animal model studies for small molecule inhibitors of DNMT1 in zebrafish (Abstract 2229), data from its preclinical compound MP529, a selective Aurora A kinase inhibitor (Abstract 3261) and new data exhibiting receptor tyrosine kinase inhibition in combination with an inhibitor of EGFR in mouse xenograft models (Abstract 5421).
If DNMT1 is overexpressed, it may hypermethylate and silence tumour suppressor genes possibly leading to or advancing cancer.
DNMT3A, a de novo DNA methyltransferase, establishes the patterns of methylation in early embryonic development, along with DNMT3B, and cooperates with DNMT1 to maintain the methylation of repetitive sequences such as LINE-1 and Alu elements (Jones and Liang 2009).
One of these MBDs is MeCP2, which represses gene transcription via coordinated binding of methylated DNA, HDACs, and DNMT1 (Ballestar and Wolffe 2001).
The company also presented new animal model studies for small molecule inhibitors of DNMT1 in zebrafish (Abstract 2229), data from its preclinical compound MP529, a selective Aurora A kinase inhibitor (Abstract 3261) and new data exhibiting receptor tyrosine kinase inhibition in combination with an inhibitor of EGFR in mouse xenograft models (Abstract 5421).
In a poster entitled "Decreased Expression of DNMT1 at the mRNA Level Following 7-day Infusion of the Antisense Compound MG98 in a Phase I Study," patients received a continuous infusion of MG98 over 7 days, with a break of 7 days between cycles.
Both DNMT1 rs10854076 and DNMT1 rs2228611 polymorphisms modified associations between urinary cadmium and LINE-1 (p-values for interaction in adjusted models were 0.
Zebrafish as a model #2229 April mechanistic screen 16 for small molecule Poster inhibitors of DNMT1 Section 23 Monday, 1 p.