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DNCB forms dinitrophenyl protein by interacting with the skin (Sajid et al.
A standard method for DNCB sensitization testing in patients with neoplasma.
To investigate the effects of RS on ACD, the mice were randomly assigned to one of seven groups (n = 8 per group): normal, model (DNCB-induced ACD mice), Dex (Dex + DNCB-treated mice), and another four groups in which the mice were treated with DNCB + different doses of RS extract (1.
To study the effects on T cells and their subsets, we applied DNCB to induce the initial stage of ACD (Fig.
Topical application of DNCB results in activation of T-cells.
Induction of hair growth in alopecia areata with DNCB.
25 ml (approximately 5 drops) of 2% DNCB Acetone fluid was dripped onto the rats each day for 14 days.
A previous study reported that IgE and TARC, which are elevated in AD, were induced by the chemical hapten, DNCB (Choi et al.
Elevated serum IgE is known to cause both acute and chronic AD-like skin symptoms, and repeated application with DNCB elevated serum IgE levels in NC/Nga mice.
It was anticipated that only the group of mice administered with 10 mg/kg showed a significant reduction in the mean values of skin thickness when compared with the mean values of other groups after applying a sensitizing dose of DNCB (Table III).
In our study, DNCB was used because it activates T-cells by forming di-nitro phenyl protein complexes with various skin proteins and thus develops delayed type hypersensitivity responses.
Cellular immunity was determined in all the groups (A1, B1, C1, D1, E1 and F1) through DNCB and MEA in groups (A2, B2, C2, D2, E2 and F2).
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