DNA vaccine


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Related to DNA vaccine: recombinant vaccine, PubMed

DNA vaccine

a vaccine employing naked DNA from an organism to which immunity is intended to be conveyed; use remains in experimental stages..
A technique for protecting an organism against disease by injecting it with genetically engineered DNA to produce an immune response. This experimental vaccine carries a gene that encodes a protein responsible for an immune reaction against the pathogen of interest, which may be directly injected IM
Molecular medicine A vaccine in which a simple injection of a gene evokes the desired immune response to the protein encoded by the gene
Potential DNA vaccines Influenza, herpes, malaria, HIV, HPV, TB, chlamydia, hepatitis

DNA vaccine

an experimental VACCINE technology in which one or more genes encoding specific ANTIGENS are directly injected into the body, with a view to antigen production and stimulation of the IMMUNE RESPONSE. Such vaccines include several HIV genes. The technology would be useful for the production of inexpensive and heat-stable vaccines.

vaccine

a suspension of attenuated or killed microorganisms (viruses, bacteria or rickettsiae), administered for prevention, amelioration or treatment of infectious diseases.

anti-idiotype vaccine
antibody made to antigenic determinants located in the variable domains of immunoglobulin molecules. Proposed as a means of regulating antibody responses and also as a substitute antigen for vaccination.
vaccine-associated sarcoma
see sarcoma.
attenuated vaccine
a vaccine prepared from live microorganisms that have lost their virulence but retained their ability to induce protective immunity. Attenuated microorganisms including particularly bacteria and viruses may be found naturally or they may be produced in the laboratory, for example by adaptation to a new medium or cell culture or they may be produced by recombinant DNA technology.
autogenous vaccine
a vaccine prepared from cultures of material derived from a lesion of the animal to be vaccinated, e.g. wart vaccine.
bacterial vaccine
a preparation of attenuated or killed bacteria, used to immunize against organisms injected, or sometimes for pyrogenetic effects in treatment of certain noninfectious diseases.
biosynthetic vaccine
a formulation containing a protective, noninfectious, immunogenic subunit produced in or by a biological system.
caprinized vaccine
a vaccine, usually a virus, attenuated by serial passage through goats, e.g. caprinized rinderpest vaccine. In highly susceptible cattle this vaccine may cause significant reactions and lapinized vaccines are preferred.
core vaccine
one that should always be included in the basic immunization program for the species.
dead vaccine
inactivated vaccine; one with organisms that have been killed.
DNA vaccine
DNA sequences that code for immunogenic proteins located in appropriately constructed plasmids which include strong promoters, which when injected into an animal are taken up by cells and the immunogenic proteins are expressed and elicit an immune response. No vaccines of this type are licensed and concerns about safety have not been resolved.
heterotypic vaccine
one developed from a virus that is antigenically distinct but related to that causing the disease for which the animal is being immunized, e.g. measles vaccine used to protect dogs from canine distemper.
homotypic vaccine
one developed from the same virus as that causing the disease the animal is being immunized against.
human diploid cell vaccine
an inactivated rabies vaccine made from rabies virus grown on human embryo lung fibroblast cells.
inactivated vaccine
see dead vaccine (above).
killed virus (KV) vaccine
see dead vaccine (above).
live vaccine
a vaccine prepared from live, usually attenuated, microorganisms.
vaccine lymph
material containing vaccinia virus collected from vaccinial vesicles of inoculated calves; used for active immunization against smallpox.
mixed vaccine
see mixed bacterial vaccine.
modified live virus (MLV) vaccine
see attenuated vaccine (above).
polyvalent vaccine
one prepared from more than one strain or species of microorganisms.
recombinant vaccine
one created by recombinant DNA technology.
subunit vaccine
one containing only specific antigenic proteins of the infectious agent.
synthetic peptide vaccine
using synthetic short peptides which correspond with major epitopes of viral proteins to elicit a protective antibody response.
virus-vectored vaccine
use of viruses as vectors to carry selected genes from another virus for immunization.
References in periodicals archive ?
NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that a scientific paper demonstrating strong and protective immune responses from candidate SynCon[TM] DNA vaccines in preclinical studies using Inovio's intradermal (ID) DNA delivery technology was one of the top cited scientific articles in the past three years in the journal Vaccine.
While we have already reported best-in-class T cell responses from two DNA vaccines in human trials, this published study shows for the first time how DNA-based IL-33 can boost antigen-specific immune responses generated by our DNA immunotherapies and vaccines.
To elicit protective levels of antibodies in the majority of non-responders with our PowderJect hepatitis B DNA vaccine is a great achieve-ment.
The researchers also haven't nailed down the best age at which to administer the DNA vaccine to people.
This special edition of Expert Review of Vaccines focuses on the development progress of DNA vaccines for human use, and features articles on general methodology of DNA vaccines, such as manufacturing, delivery technologies, primeboost strategies and regulatory issues.
In a prior study in mice, INO-5150 immunization induced potent antibody and T cell responses, providing initial evidence that its concept for a therapeutic DNA vaccine comprising a broader collection of antigens, administered with Inovio's electroporation-based delivery technology, would improve the breadth and effectiveness of a prostate cancer immunotherapy.
Khavari and his colleagues have not yet shown that a skin application of a DNA vaccine protects animals from a virus or bacterium.
Joseph Kim, President and CEO, said, "We greatly appreciate this recognition of Inovio's leadership and innovation in advancing the amazing protective capabilities provided by vaccines over the last century to potentially provide with our DNA vaccines better prevention and treatment of cancers and challenging infectious diseases.
The article also compares several DNA vaccine delivery technologies, coming to the conclusion that, "The immune responses and protection from pathogen challenge observed following DNA administration via EP in many cases are comparable or superior to other well studied vaccine platforms including viral vectors and live/attenuated/inactivated virus vaccines.
By contrast, the DNA vaccine could be provided for as little as 5 to 10 cents a shot, Lodmell says.
These proof-of-concept results have recently been supported by positive immunology data from Inovio's phase I clinical study of its multi-antigen SynCon(TM) DNA vaccine against cervical dysplasias (VGX-3100).
This DNA vaccine strategy has been somewhat difficult to test, notes Sadoff, because S.