DNA vaccine

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DNA vaccine

a vaccine employing naked DNA from an organism to which immunity is intended to be conveyed; use remains in experimental stages..
A technique for protecting an organism against disease by injecting it with genetically engineered DNA to produce an immune response. This experimental vaccine carries a gene that encodes a protein responsible for an immune reaction against the pathogen of interest, which may be directly injected IM
Molecular medicine A vaccine in which a simple injection of a gene evokes the desired immune response to the protein encoded by the gene
Potential DNA vaccines Influenza, herpes, malaria, HIV, HPV, TB, chlamydia, hepatitis

DNA vaccine

an experimental VACCINE technology in which one or more genes encoding specific ANTIGENS are directly injected into the body, with a view to antigen production and stimulation of the IMMUNE RESPONSE. Such vaccines include several HIV genes. The technology would be useful for the production of inexpensive and heat-stable vaccines.

vaccine

a suspension of attenuated or killed microorganisms (viruses, bacteria or rickettsiae), administered for prevention, amelioration or treatment of infectious diseases.

anti-idiotype vaccine
antibody made to antigenic determinants located in the variable domains of immunoglobulin molecules. Proposed as a means of regulating antibody responses and also as a substitute antigen for vaccination.
vaccine-associated sarcoma
see sarcoma.
attenuated vaccine
a vaccine prepared from live microorganisms that have lost their virulence but retained their ability to induce protective immunity. Attenuated microorganisms including particularly bacteria and viruses may be found naturally or they may be produced in the laboratory, for example by adaptation to a new medium or cell culture or they may be produced by recombinant DNA technology.
autogenous vaccine
a vaccine prepared from cultures of material derived from a lesion of the animal to be vaccinated, e.g. wart vaccine.
bacterial vaccine
a preparation of attenuated or killed bacteria, used to immunize against organisms injected, or sometimes for pyrogenetic effects in treatment of certain noninfectious diseases.
biosynthetic vaccine
a formulation containing a protective, noninfectious, immunogenic subunit produced in or by a biological system.
caprinized vaccine
a vaccine, usually a virus, attenuated by serial passage through goats, e.g. caprinized rinderpest vaccine. In highly susceptible cattle this vaccine may cause significant reactions and lapinized vaccines are preferred.
core vaccine
one that should always be included in the basic immunization program for the species.
dead vaccine
inactivated vaccine; one with organisms that have been killed.
DNA vaccine
DNA sequences that code for immunogenic proteins located in appropriately constructed plasmids which include strong promoters, which when injected into an animal are taken up by cells and the immunogenic proteins are expressed and elicit an immune response. No vaccines of this type are licensed and concerns about safety have not been resolved.
heterotypic vaccine
one developed from a virus that is antigenically distinct but related to that causing the disease for which the animal is being immunized, e.g. measles vaccine used to protect dogs from canine distemper.
homotypic vaccine
one developed from the same virus as that causing the disease the animal is being immunized against.
human diploid cell vaccine
an inactivated rabies vaccine made from rabies virus grown on human embryo lung fibroblast cells.
inactivated vaccine
see dead vaccine (above).
killed virus (KV) vaccine
see dead vaccine (above).
live vaccine
a vaccine prepared from live, usually attenuated, microorganisms.
vaccine lymph
material containing vaccinia virus collected from vaccinial vesicles of inoculated calves; used for active immunization against smallpox.
mixed vaccine
see mixed bacterial vaccine.
modified live virus (MLV) vaccine
see attenuated vaccine (above).
polyvalent vaccine
one prepared from more than one strain or species of microorganisms.
recombinant vaccine
one created by recombinant DNA technology.
subunit vaccine
one containing only specific antigenic proteins of the infectious agent.
synthetic peptide vaccine
using synthetic short peptides which correspond with major epitopes of viral proteins to elicit a protective antibody response.
virus-vectored vaccine
use of viruses as vectors to carry selected genes from another virus for immunization.
References in periodicals archive ?
However by generating a number of fingerprints, sensitivity can be increased and minor changes in the pDNA could be detected and their impact on DNA vaccination or DNA therapy can be investigated.
Furthermore, SRIPs DNA vaccination also elicited cytotoxic T-cell responses, thus providing additional mechanisms of protection compared to conventional non-replicating DNA and inactivated virus vaccines.
This is the first demonstration of a beneficial effect of DNA vaccination in a clinical trial of autoimmune disease.
De Rose et al (27) attempted the DNA vaccination of Merino crossbred sheep against B.
DNA vaccination at doses of 50 [micro]g/mouse (unless noted otherwise in a figure legend) in low-endotoxin PBS (AccuGENE, Cambrex, East Rutherford, NJ, USA) was given intramuscularly in the quadriceps, half to each leg, in 3 doses 2 weeks apart.
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine augmented DNA vaccination.
A company statement said: "The studies, carried out in a widely accepted laboratory model for HIV, demonstrate that DNA vaccination via the PowderJect System results in an unprecedentedly high cellular immune response".
Vaccine Safety Refusal to Immunize Obesity Post-Licensure Surveillance The Future of Vaccine Safety Vaccine Shortages Preventing Pandemics Project Bioshield Act National Bio and Agro-Defense Facility DNA Vaccination Mucosal Delivery Intranasal Delivery Vaccine Patches Vaccine Chips and Microneedles Innovations in Vaccine Production Nanoparticle Systems Cloning Read the full report: http://www.
Researchers from a number of countries review the literature on such aspects as anti-ergotypic regulatory T-cells, regulatory mechanisms induced by t-cell vaccination in humans, peptide and DNA vaccination in experimental allergic encephalomyelitis (EAE) and multiple sclerosis, and regulatory anti-T-cell antibodies induced by T-cell vaccination.
Yet another approach concerns DNA vaccination in humans by using plasmids that express [greater than or equal to] 1 foreign gene.
Overall, the company has more than 400 issued or pending patents worldwide, with extensive coverage in the field of naked DNA gene delivery for DNA vaccination and gene-based protein delivery.
Even so, he says, measles vaccination may evolve into a two-step process, with a DNA vaccination in the first months of life and a standard immunization later.