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DNA topoisomerase

   Also found in: Wikipedia 0.02 sec.
DNA topoisomerase /DNA topo·isom·er·ase/ (to″po-i-som´er-ās) either of two types of isomerase that catalyze the breakage, passage, and rejoining of one or both DNA strands, type I topoisomerases specific for single-strand passage and type II for double; thus altering the topology of the molecule.


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a DNA topoisomerase inhibitor used as the hydrochloride salt as an antineoplastic in the treatment of colorectal carcinoma.
a DNA topoisomerase inhibitor used as the hydrochloride salt as an antineoplastic in the treatment of colorectal carcinoma.
The third mutation was in the parC gene, which encodes DNA topoisomerase IV, at codon 84 (GAA to AAA), which substitutes lysine for glutamic acid.
 
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