DNA topoisomerase


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Related to DNA topoisomerase: DNA gyrase

DNA topoisomerase

/DNA topo·isom·er·ase/ (to″po-i-som´er-ās) either of two types of isomerase that catalyze the breakage, passage, and rejoining of one or both DNA strands, type I topoisomerases specific for single-strand passage and type II for double; thus altering the topology of the molecule.
References in periodicals archive ?
pneumoniae is primarily due to mutations in the genes encoding the target topoisomerase enzymes, namely parC, which encodes the A subunit of DNA topoisomerase IV, and gyrA, which encodes the A subunit of DNA gyrase (7).
The enzyme DNA topoisomerase II (topo II) is the target of several clinically useful anticancer drugs, including etoposide.
Detection of the pine wood nematode using a real-time PCR assay to target the DNA topoisomerase I gene.
The nucleotide sequences obtained for the fragments of the DNA polymerase, DNA topoisomerase, and virus late transcription factor-3 of the clinical specimens were aligned with sequences from other poxviruses available in the public database (GenBank).
Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols, J.
Ribonuclease activity of vaccinia DNA topoisomerase IB: kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay.
In general, strains that shared the same PFGE pattern shared identical polymorphisms on their DNA topoisomerase QRDRs with respect to the sequence of the R6 strain (Table 3).
The third mutation was in the parC gene, which encodes DNA topoisomerase IV, at codon 84 (GAA to AAA), which substitutes lysine for glutamic acid.
The catalytic Topo II inhibitors include a variety of compounds that interfere with the binding between DNA and topoisomerase, stabilise noncovalent DNA topoisomerase complexes, or inhibit Topo II-ATP binding (Larsen et al.
Various studies have shown evidence for potential recombination mediating features, including a DNA topoisomerase II cleavage site, a DNase I hypersensitivity site and recombination signal sequences for V(D)J gene segment joining.
These MLL fusions often follow treatment with drugs which interfere with DNA topoisomerase II (topo II) activity and implicate topo II in the translocation mechanism, in vivo.