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DNA topoisomerase

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DNA topoisomerase /DNA topo·isom·er·ase/ (to″po-i-som´er-ās) either of two types of isomerase that catalyze the breakage, passage, and rejoining of one or both DNA strands, type I topoisomerases specific for single-strand passage and type II for double; thus altering the topology of the molecule.


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9780879698799 Untangling the double helix; DNA entanglement and the action of the DNA topoisomerases.
Resistance is caused mainly by amino acid changes in quinolone resistance-determining regions (QRDRs) of the subunits of DNA topoisomerase IV (topo IV; [parC.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
 
 
 
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