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DNA topoisomerase |
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DNA topoisomerase /DNA topo·isom·er·ase/ (to″po-i-som´er-ās) either of two types of isomerase that catalyze the breakage, passage, and rejoining of one or both DNA strands, type I topoisomerases specific for single-strand passage and type II for double; thus altering the topology of the molecule. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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a DNA topoisomerase inhibitor used as the hydrochloride salt as an antineoplastic in the treatment of colorectal carcinoma. a DNA topoisomerase inhibitor used as the hydrochloride salt as an antineoplastic in the treatment of colorectal carcinoma. The third mutation was in the parC gene, which encodes DNA topoisomerase IV, at codon 84 (GAA to AAA), which substitutes lysine for glutamic acid. |
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