CDKN1A

(redirected from DNA synthesis inhibitor)

CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.
References in periodicals archive ?
Piritrexim, a DNA synthesis inhibitor, is being developed for the treatment of bladder cancer, early stage Kaposi's sarcoma and other cancers.
2001) also showed that CPF is a stronger DNA synthesis inhibitor than CPF-oxon, although it is a weaker cholinesterase inhibitor.
Other categories include RNA and DNA synthesis inhibitors, as well as bacterial cell wall and membrane disruptors.