CDKN1A

(redirected from DNA synthesis inhibitor)

CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.
References in periodicals archive ?
2001) also showed that CPF is a stronger DNA synthesis inhibitor than CPF-oxon, although it is a weaker cholinesterase inhibitor.
Piritrexim, a DNA synthesis inhibitor, is being developed for the treatment of bladder cancer, early stage Kaposi's sarcoma and other cancers.
Other categories include RNA and DNA synthesis inhibitors, as well as bacterial cell wall and membrane disruptors.