of Gladstone Institute of Neurological Disease, San Francisco, and her colleagues found low levels of BRCA1 protein, a DNA repair enzyme, in the brains of deceased Alzheimer's and mild cognitive impairment patients, compared with controls, as well as in mouse models of Alzheimer's.
For many years, scientists have known that viruses rely on functions provided by their host cells to increase their numbers, but the UCI study - led by microbiology and molecular genetics professor Bert Semler - is the first to identify how the RNA-containing picornaviruses utilize a DNA repair enzyme to do so.
Two phase II trials of gefitinib are underway in patients with squamous cell carcinoma and topical therapies on the horizon include T4 endonuclease V, a bacterial DNA repair enzyme that increases the rate of repair of sunlight-induced DNA damage in human cells, Dr.
Several SNPs and somatic mutations have been characterized in a human 8-hydroxyguanine glycosylase gene, OGG1, which codes for a DNA repair enzyme responsible for excising 8-hydroxyguanine from damaged DNA (1, 2).
has announced that the National Cancer Institute intends to conduct a one-year clinical trial of its Dimericine, a topical liposomal DNA repair enzyme, to reduce the rate of skin cancer in renal transplant patients.