DNA repair enzyme

DNA repair enzyme

(1) DNA ligase (ATP), EC 6.5.1.1.
(2) DNA ligase (NAD+), EC 6.5.1.1.
References in periodicals archive ?
These results are similar to data obtained with the DNA repair enzyme Ogg1 and indicate the dependence of inhibition on the presence of free metal ions in solution (Zharkov and Rosenquist 2002).
These findings are significant because all known picornaviruses harbor the target for this DNA repair enzyme, despite the fact that their genetic material is made up of RNA rather than DNA.
Several SNPs and somatic mutations have been characterized in a human 8-hydroxyguanine glycosylase gene, OGG1, which codes for a DNA repair enzyme responsible for excising 8-hydroxyguanine from damaged DNA (1, 2).
has announced that the National Cancer Institute intends to conduct a one-year clinical trial of its Dimericine, a topical liposomal DNA repair enzyme, to reduce the rate of skin cancer in renal transplant patients.
DelMar has demonstrated that VAL-083's anti-tumor activity is unaffected by the expression of MGMT, a DNA repair enzyme that is implicated in chemotherapy resistance and poor outcomes in GBM patients following standard front-line treatment with temozolomide.
We have previously shown that VAL-083's anti-tumor activity is unaffected by the expression of MGMT, a DNA repair enzyme that is implicated in chemotherapy resistance.
Researchers from Melbourne University, Dr Linda Feketeova and Dr Uta Wille, along with Austrian scientists from the University of Innsbruck are looking at a DNA repair enzyme found in kangaroos.
It was found that one DNA repair enzyme they studied, Ntg1, moves to the nucleus or the mitochondria depending on where DNA damage is concentrated.
Our results are the first to identify a potential DNA repair enzyme target for lead and suggest a means by which these prevalent environmental metals may elicit their deleterious effects.
VAL-083 maintains anti-tumor activity independent of DNA repair enzyme 0-6-methylguanine DNA methyltransferase (MGMT) resistance mechanism; and
NIEHS researchers are in the process of resequencing DNA repair enzyme and cell cycle control genes.