DNMT1

(redirected from DNA methyltransferase 1)

DNMT1

A gene on chromosome 19q13.2 that encodes a DNA (cytosine-5-)-methyltransferase 1, which methylates CpG residues and plays a critical role in establishing and regulating tissue-specific patterns of cytosine methylation.

Molecular pathology
Aberrant methylation patterns are associated with certain human tumours (e.g., breast carcinoma) and developmental
abnormalities.
References in periodicals archive ?
771) investigated the potential role of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic-induced toxicity.
Poster Session -- #765 - AML1/ETO Associates with DNA Methyltransferase 1 (DNMT1) in Inducing Transcriptional Repression of the AML1-Target Gene Interleukin-3 (IL-3): Oral Session -- #775 - Activation of the Silenced MLL (ALL-1) Wild-Type Allele in Acute Myeloid Leukemia (AML) with the MLL Partial Tandem Duplication Results in Enhancement of Cell Death: Oral Session -- #1412 - Combined Effect of Phenylbutyrate and 5-aza-2'-deoxycytidine (decitabine) in t(8;21) AML Leukemia Cells in Vitro and In Vivo: Poster Session -- #2295 - Preclinical Studies of the Combination of the Hypomethylating Agent 5-aza-2'-Deoxycytidine (Decitabine) and the Histone Deacetylase Inhibitor (HDI) Valproic Acid (VPA) in Leukemic Cell Systems.
Rationale: DNA methylation has been postulated to play an important role in tumour progression and therefore the reduction of DNA methylation by the inhibition of DNA methyltransferase 1 (DNMT1) may result in anticancer activity.
The data demonstrated that MG98 possessed antitumour activity and provided sustained reduction in DNA methyltransferase 1 (DNMT1) expression.
In addition, we observed down-regulation of DNA methyltransferase 1 (Dnmt1) and suppressor of variegation 3-9 homolog 1, a histone lysine methyltransferase (Suv39h1), and up-regulation of the histone demethylase Jumonji domain 2 (Jmjd2a), proteins responsible for the accurate maintenance of the epigenetic marks.
2006) to assess the status of histone H3 lysine 9 (H3K9), histone H3 lysine 27 (H3K27), and histone H4 lysine 20 (H4K20) trimethylation, as well as protein levels of DNA methyltransferase 1 (Dnmtl), histone lysine methyltransferases Suv39hl and Suv4-20hl, histone demethylase Jumonji domain 2 (Jmjd2a), and [beta]-actin.
MG98 is a second-generation antisense oligonucleotide that inhibits the synthesis of DNA methyltransferase 1.
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.
MG98 is a second generation antisense oligonucleotide that inhibits the synthesis of DNA methyltransferase 1.
MG98 is a second generation antisense oligonucleotide that inhibits the synthesis of DNA methyltransferase 1 (DNMT1), resulting in reactivation of methylation-silenced tumor suppressor genes in cancer cells.