DNA methyltransferase


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DNA methyltransferase

An enzyme that adds methyl groups to DNA (nucleic acids) so as to modify gene expression.

Types of DNA methyltransferase
• DNMT1—Responsible for hemimethylated CpG island methylation.
• TRDMT1 (formerly DNMT2, renamed tRNA aspartic acid methyltransferase 1)—Transfers methyl groups to RNA.
• DNMT3—Responsible for unmethylated CpG island methylation.
References in periodicals archive ?
CpG sites are regions of DNA wherein a cytosine nucleotide becomes methylated through DNA methyltransferase enzymes which have the net effect of suppressing gene transcription.
Researchers found that theaflavin-3 (TF-3), the antioxidant, works by inhibiting the function of an enzyme called DNA methyltransferase, which destroys bone tissue.
VAL-083 maintains anti-tumor activity independent of DNA repair enzyme 0-6-methylguanine DNA methyltransferase (MGMT) resistance mechanism; and
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.
Researchers found that theaflavin3 (TF3), the antioxidant, works by inhibiting the function of an enzyme called DNA methyltransferase, which destroys bone tissue.
Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism.
The virus increased the presence of an enzyme called DNA methyltransferase.
The virus contained extra copies of a gene that makes an enzyme called DNA methyltransferase (Dnmt3a2).
Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
Further investigation revealed that HDA6 binds directly to transposons and silences their activity through specific histone modifications, and that another enzyme, the DNA methyltransferase MET1, cooperates with HDA6 in this gene silencing.
6]-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study.