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DNA helicase

   Also found in: Wikipedia 0.07 sec.
DNA helicase,
an enzyme that catalyzes the energy-dependent unwinding of the DNA double helix during DNA replication.


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17 Cell, Bloom's syndrome results from mutations in the gene needed to produce an enzyme classified as a DNA helicase.
Gene for rare disease gives cancer clues by Seachrist, Lisa / Science News
In January 2005, Alnylam granted an exclusive license through its InterfeRx licensing program to GeneCare, a Japanese biotechnology firm, to discover, develop, and commercialize RNAi therapeutics directed against two DNA helicase genes associated with cancer.
Alnylam Pharmaceuticals Reports First Quarter 2005 Financial Results; ... by Business Wire
In both cases, fluoroquinolones appear to trap the enzyme on DNA during the topoisomerization reaction, forming a physical barrier to the movement of the replication fork (4), RNA polymerase (5), and DNA helicase (6).
Emerging Mechanisms of Fluoroquinolone Resistance by Hooper, David C. / Emerging Infectious Diseases
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