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DNA gyrase |
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Development of resistance to fluoroquinolones is a stepwise process, involving spontaneous mutations in the genes encoding the target enzymes DNA gyrase and the topoisomerase IV. Quinolones are anti-infective compounds that inhibit the activity of DNA gyrase, an enzyme necessary for bacterial growth. Species of the isolates were identified by using flaB and DNA gyrase B subunit gene (gyrB) sequencing analysis. |
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