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DNA gyrase

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DNA gyrase (ji“ras) a type II DNA topoisomerase.

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Development of resistance to fluoroquinolones is a stepwise process, involving spontaneous mutations in the genes encoding the target enzymes DNA gyrase and the topoisomerase IV.
Quinolones are anti-infective compounds that inhibit the activity of DNA gyrase, an enzyme necessary for bacterial growth.
Species of the isolates were identified by using flaB and DNA gyrase B subunit gene (gyrB) sequencing analysis.
 
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