DNA chip


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An array of DNA oligonucleotides synthesised in situ by photomasking on a semiconductor chip

DNA chip

a wafer of silicon (about 2cm2) carrying an orderly, high density array of OLIGONUCLEOTIDE PROBES (about 20 - 80 nucleotides), either synthesized in situ on the surface of the chip using, for example, laser lithography, or synthesized conventionally and then immobilized on the chip. Each probe is at a precisely defined location on the chip.

The basic procedure for using DNA chips is similar to that for DNA MICROARRAYS.

References in periodicals archive ?
Masrom, Mohammadreza abbasy (2011), An efficient cryptographic protocol based on DNA chip,[C] 2011 Published by Elsevier Ltd.
Going forward, DNA Chip Research will introduce a special-purpose chip or diagnostic chip to the 3D-Gene series.
DNA chips have been used to identify the "biomarkers" of an exposure to an alleged toxin in an individual by looking for telltale cellular changes linked to exposure.
Rosetta Inpharmatics' technology generates coherent gene expression data from DNA chips or microarrays, and applies powerful genomic analysis tools to provide comprehensive, simultaneous information about all relevant genes and targets within a cell.
Using the so-called DNA chip, they can study tens of thousands of genes at the same time and see how they vary in different tissues and how they respond to different drugs.
DNA chip technology is allowing scientists to look at the functions of the cell and to understand gene expression under a variety of stimuli.
Two French companies recently began a project to develop a DNA chip that can screen for water contamination.
The DNA chip resulted from a $10 million research and development effort by Lyonnaise des Eaux, the world's leading water management company, and bio-Merieux, a biological diagnostic company.
The research laboratories of the French companies La Lyonnaise des Eaux and BioMerieux have developed a new technique for monitoring water quality, using a DNA chip capable of recognising germs through their genetic imprint.
The researchers used DNA chip technology to monitor this gene activity in tumour cells and have compared it with healthy cells.
Tokyo, Japan, May 11, 2006 - (JCN) - Roche Diagnostics announced on May 9 that it will launch AmpliChip CYP 450, its proprietary DNA chip for gene polymorphism analysis, on May 11.
The numerical calculations illustrating this approach are based on recent DNA chip studies of point mutation in the K-ras gene (6, 10).