DNA chip


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An array of DNA oligonucleotides synthesised in situ by photomasking on a semiconductor chip

DNA chip

a wafer of silicon (about 2cm2) carrying an orderly, high density array of OLIGONUCLEOTIDE PROBES (about 20 - 80 nucleotides), either synthesized in situ on the surface of the chip using, for example, laser lithography, or synthesized conventionally and then immobilized on the chip. Each probe is at a precisely defined location on the chip.

The basic procedure for using DNA chips is similar to that for DNA MICROARRAYS.

References in periodicals archive ?
To date, a few companies have commercialized DNA chip products, but many more underlying scientific principles remain to be discovered before these devices are ready for routine clinical use.
Although DNA chips encompassing fly genes will unleash a torrent of data, some scientists caution that the information won't make sense without years of follow-up research.
Table 6: World Long-term Projections for DNA Chips by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-79
Table 8: World Historic Review for DNA Chips by GeographicRegion - US, Canada, Japan, Europe, and Rest of World MarketsIndependently Analyzed with Annual Sales Figures in US$Million for Years 2003 through 2008 (includes correspondingGraph/Chart) II-89
The developed DNA chip based on electrocopolymerization on gold electrodes gives a support with low autofluorescence, allowing the detection of <10% of mutated sequences within a mixed mutant/wild-type population.
The third type of DNA chip is the "lab-on-a-chip", microfluidic systems that perform all the steps of molecular genetic analysis on a chip.
That's a job perfectly suited to a DNA chip, says Hacia.
Toshiba emerged as an important contributor to the biotech science that integrates techniques drawn from medicine and genomics, through its development of an electrochemical DNA chip that is able to analyze and type DNA sequences that can be used to identify genes.
Further, Toray and DNA Chip Research will proceed with research with a view to developing DNA chips for diagnosis of diseases, especially cancer and life-style related diseases, within two years.
The protein chip market is relatively small compared to the DNA chip market, and its products and customers are generally quite different.
In addition, DNA Chip Research has concluded a licensing agreement with SIGMA-ALDRICH Japan.
introduced a series of DNA chips for genetic testing and other applications.