In SA, commencement of biologic therapy after a 6-month trial of at least 3 synthetic DMARDs
(including MTX, unless contraindicated) seems reasonable, given resource constraints, and given that up to one-third of patients will achieve LDA on synthetic DMARD
A phase III, multicenter, double-blind, randomized, controlled withdrawal study was conducted with abatacept in 190 patients with active poly-JIA despite at least one DMARD
Additionally, when adjusting for other risk factors for diabetes, researchers found a reduced relative risk of diabetes in patients treated with TNF inhibitors and hydroxychloroquine compared with other non-biologic DMARDs
etkilerine yonelik iyi veriler yetersiz duzeydedir; i yi metodoloji ve yeterli sayida hastayi iceren calismala ra gereksinim vardir.
In a large community-based study concerning the problem of risk perception and unwillingness to try another DMARD
by RA patients, the patients "resistant to change" were significantly older, used fewer DMARDs
before, had lower health literacy as well as higher perception of medication risk.
For patients who lose efficacy of multiple biologic agents, consider switching to combination DMARD
therapy to avoid the issue of AABs.
Rigel believes that R406 may become a first-line DMARD
with greater efficacy, safety and improved delivery and patient compliance than injectable treatments, and thus may be used early in the course of the disease before significant bone and cartilage damage occurs.
XELJANZ should not be used in combination with biologic DMARDs
or with potent immunosuppressives, such as azathioprine and cyclosporine.
patients were required to be considered DMARD
inadequate responders (IR) other than MTX, and 3.
We compared the effects of anti-TNF therapy on hemoglobin levels with that of DMARD
therapy in the same patients before anti-TNF therapy.
4 cases per 1,000 person-years, an adjusted 36% lower risk than that in patients on a nonbiologic DMARD
, ose rate was 6.
Early therapy with combinations of conventional DMARDs
has been shown to retard the radiologic progression of RA for a period of up to 5 years, but until now the effects of initial aggressive DMARD
therapy on radiologic prognosis after that were unknown.