DLEC1

(redirected from DLC1)
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DLEC1

A gene on chromosome 3p21.3 that spans 59 kb, which may be deleted in certain malignancies and encode nonfunctional proteins. Aberrant DLEC1 transcription may be involved in carcinogenesis of the lung, oesophagus and kidney.
References in periodicals archive ?
In mice genetically engineered to over-produce DLC1, cells were found to move faster than normal, reproduce more quickly, and grow without normal cell-to-cell contacts.
The researchers traced the cancer-triggering modification to a tiny change in a chain of 19 amino acid protein building blocks in DLC1.
When his team engineered a form of DLC1 missing the modification-sensitive site, the protein no longer formed tumours.