IPO.af.5

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IPO.af.5

A gene on chromosome 13q32.2 that encodes the beta chain of the importin family of heterodimeric receptors, which import proteins into the nucleus. It is thought to mediate docking of the importin/substrate complex to the nuclear pore complex by binding to nucleoporin; the complex is then translocated through the pore by an energy-requiring, Ran-dependent mechanism.