KLF8

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KLF8

A gene on chromosome Xp11.21 that encodes a protein belonging to the Sp/KLF family of transcription factors, which contains a C-terminal DNA-binding domain with three Kruppel-like zinc finger motifs. KLF8 is thought to regulate epithelial to mesenchymal transition, a process that occurs during normal development as well as during metastasis.