PDE4B

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PDE4B

A gene on chromosome 1q31 that encodes a cyclic AMP-specific nucleotide phosphodiesterase, which plays a critical role in signal transduction by hydrolysing the second messenger cAMP to AMP, thereby playing a role in regulating physiological processes.

Molecular pathology
PDE4B alterations have been anecdotally linked to schizophrenia and bipolar disorder.