ZDHHC21

(redirected from DHHC-21)

ZDHHC21

A gene on chromosome 9p22.3 that encodes a DHHC-type zinc finger protein and palmitoyltransferase which palmitoylates sex steroid hormone receptors (e.g., ESR1, PGR and AR), regulating their targeting to plasma membranes. This enables rapid intracellular signalling by sex hormones via ERK and AKT kinases and the generation of cAMP.