DHFR


Also found in: Acronyms.

DHFR

Abbreviation for dihydrofolate reductase.

DHFR

Dihydrofolate reductase, see there.
References in periodicals archive ?
Although the precise relation between mutations in the DHFR and DHPS genes in clinical sulphadoxine-pyremethamine resistance is unclear, current data show that the presence of a sensitive DHFR allele is highly predictive of sulphadoxine-pyremethamine treatment success irrespective of the DHPS allele (51).
To overcome these limitations, investigators have taken advantage of the property of MTX to inhibit DHFR (18-20) and developed two alternative strategies.
We have adapted the DHFR enzyme inhibition assay (4,17) for use in a 96-well microplate reader.
For more information on CHOZN DHFR and other CHOZN cell lines, visit www.
Sulfadoxine-pyrimethamine efficacy and selection of Plasmodium falciparum DHFR mutations in Burkina Faso before its introduction as intermittent preventive treatment for pregnant women.
The new CHOZN DHFR-/- CHO line allows process development scientists to use any common DHFR expression system for the selection and amplification in a fully traceable CHO-K1 background.
Such forward-looking statements include statements regarding the potential safety and efficacy profile of PDX for the treatment of CTCL or any other type of cancer; the potential safety and efficacy profile of PDX relative to methotrexate and other related DHFR inhibitors; and other statements that are other than statements of historical facts.
In addition to the results of clinical and nonclinical studies of torezolid phosphate, the posters highlight advances in Trius' preclinical GyrB and DHFR antibacterial and antifungal programs.
Such forward-looking statements include statements regarding the potential for PDX to offer a new treatment option for patients with relapsed or refractory PTCL, the Company's projected timeline for reporting top line results from the PROPEL trial, the Company's intent to submit a New Drug Application for PDX as a treatment for patients with relapsed or refractor PTCL following its review of the trial results, the potential safety and efficacy profile of PDX relative to methotrexate and other related DHFR inhibitors; and other statements that are other than statements of historical facts.
The DHFR class has been proven safe and effective in more than four decades of clinical use.
Such forward-looking statements include statements regarding the potential for PDX to offer a new treatment option for patients with relapsed or refractory PTCL; the Company's projected timeline for reporting top line results of the PROPEL trial; the potential safety and efficacy profile of PDX relative to methotrexate and other related DHFR inhibitors; and other statements that are other than statements of historical facts.