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DHFR

   Also found in: Acronyms 0.03 sec.
DHFR
Dihydrofolate reductase, see there


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Multiple copies of the DHFR gene havebeen found in tumor cells of some methotrexate-resistant patients, enabling the production of above-normal amounts of DHFR.
Talvesta is a novel nonpolyglutamable antifolate drug which targets DHFR under development for the treatment of various types of cancers.
Talvesta has demonstrated enhanced antitumor activity in a broad spectrum of cancer models by targeting the enzyme DHFR to prevent DNA synthesis in tumor cells and inhibit tumor growth.
 
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