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DHFR |
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DHFR Dihydrofolate reductase, see there How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Multiple copies of the DHFR gene havebeen found in tumor cells of some methotrexate-resistant patients, enabling the production of above-normal amounts of DHFR. Talvesta is a novel nonpolyglutamable antifolate drug which targets DHFR under development for the treatment of various types of cancers. Talvesta has demonstrated enhanced antitumor activity in a broad spectrum of cancer models by targeting the enzyme DHFR to prevent DNA synthesis in tumor cells and inhibit tumor growth. |
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