DHFR


Also found in: Acronyms.

DHFR

Abbreviation for dihydrofolate reductase.

DHFR

Dihydrofolate reductase, see there.
References in periodicals archive ?
The observed activity from molecular docking analysis showed that complexes 2, 8 and 9 may exert their action through inhibition of the DHFR enzyme.
The DHFR is an effective target for various antimalarial drugs (Peterson et al.
5A) Interestingly, when conjugated to DHFR, the activity of G1M8B was markedly higher than G1M9.
5] Human genes: SLA, Src-like-adaptor; LST1, leukocyte-specific transcript 1; BENE, BENE protein; KRT24, keratin 24; C9orf3, chromosome 9 open reading frame 3; KIAA0779, KIAA0779 protein; TMCC1, transmembrane and coiledcoil domain family 1; ZNF292, zinc finger protein 292; LOC153222, adult retina protein; CBEP4, cytoplasmic polyadenylation element binding protein4; TICD2, tigger transposable element derived 2; UBAP2, ubiquitin associated protein 2; AVPI1, arginine vasopressin-induced 1; KIAA0669, the same as TSC22D2; TSC22D2, TSC22 domain family, member 2; DHFR, dihydrofolate reductase; MTR, 5-methoyltetrahydrofolate-homocysteine methyltransferase; ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide; KA36, type I hair keratin; KRT4, Keratin 4; KRT9, Keratin 9.
Scientists say the key lies in a protein called DHFR, which the parasite produces to keep itself alive.
Fusion peptides consisting of N- and C-terminal fragments of murine DHFR fused to-GCN4 leucine zipper sequences were coexpressed in Escherichia coli grown in minimal medium, where the endogenous DHFR activity was inhibited with trimethoprim.
Multiple copies of the DHFR gene havebeen found in tumor cells of some methotrexate-resistant patients, enabling the production of above-normal amounts of DHFR.
He attributes this inability to having inherited a variant in the DHFR (dihydrofolate reductase) gene that lowers the ability of DHFR to reduce dihydrofolate into tetrahydrofolate (BH4), which is essential for breaking down histidine, from which histamine is synthesized.
In brief, multiplex qPCR amplification of TaqMan probe sets (Applied Biosvstems, Carlsbad, CA) for DHFR and GTP cyclo-hydroiase (GTPCH) with respect to [beta]-actin was performed using a 7500 Fast Real-Time PCR System (Applied Biosystems).