MYO15A

(redirected from DFNB3)

MYO15A

A gene on chromosome 19p13.1 that encodes a protein belonging to the myosin family of actin-based molecular motor heavy chain proteins, which binds calmodulin, which serves as a light chain. The MYOB/calmodulin complex displays processive movement on actin filaments toward the minus-end.

Molecular pathology
MYOB polymorphisms are associated with coeliac disease and ulcerative colitis.
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References in periodicals archive ?
Large cohort consanguineous families with hereditary deafness show DFNB4/PDS locus as the predominant cause followed by DFNB1, DFNB2/USH1B, DFNB3 and DFNB12/USH1D, DFNB8/10 and DFNB7/11 in Pakistani population.
Recessive mutations of MYO15 causes profound hearing impairment DFNB3 is responsible for 5% of recessive deafness in Pakistani population (Friedman et al.
DFNB3, spectrum of MYO15A recessive mutant alleles and an emerging genotype-phenotype correlation.