DES (redirected from DES (disambiguation))

DES diethylstilbestrol.

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DES (d-s)

n.

Diethylstilbestrol; a synthetic nonsteroidal substance having estrogenic properties and once used to treat menstrual disorders. It is no longer used due to the incidence of certain vaginal cancers in the daughters of women so treated.

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DES

The abbreviation for diethylstilbestrol, a synthetic form of estrogen that was widely prescribed to women from 1940 to 1970 to prevent complications. It was linked to several serious birth defects and disorders of the reproductive system in daughters of women who took DES. In 1971, the FDA suggested it not be used during pregnancy and banned its use in 1979 as a growth promoter in livestock.

Mentioned in: Colposcopy

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DES,

abbreviation for diethylstilbestrol.

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DES

diethylstilbestrol.

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DES

Diethylstilbestrol Gynecology A synthetic estrogen more potent than natural estrogens; DES use during pregnancy was banned in 1972, as in utero exposure before the 18^th gestational wk results in a 3-fold ↑ in congental abnormalities–without impairing fertility or sexual function—and vaginal wall adenosis in 35-70% of exposed ♀ infants; 0.14% of cases progress to vaginal adenocarcinoma; other DES changes include obliteration of vaginal fornices, microglandular hyperplasia of the cervix–cervical ectropion, transverse ridging–appearance, and a 2.5-fold ↑ in 1º infertility Treatment Aggressive surgery–eg, vaginectomy, hysterectomy and lymphadenectomy. See Cockscomb cervix.