DES


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diethylstilbestrol

 (DES) [di-eth″il-stil-bes´trol]
a synthetic nonsteroidal estrogen used for palliative treatment of prostatic carcinoma and sometimes advanced breast carcinoma. It was formerly used to relieve vasomotor symptoms associated with menopause, and in primary ovarian failure, female hypogonadism, atrophic vaginitis, kraurosis vulvae, and female castration. Most significantly, however, it was formerly widely used to prevent threatened abortion and premature labor. The female children who were thus exposed to the drug as fetuses have tended to have a variety of cervical abnormalities and an increased risk of clear cell adenocarcinoma of the reproductive tract. Male offspring have sometimes had abnormal genitalia, epididymal cysts, and abnormal semen analyses. Regular examinations and follow-up are indicated for these individuals.

DES

Abbreviation for diethylstilbestrol.

DES

diethylstilbestrol.

DES

abbr.
1. data encryption standard
2. diethylstilbestrol

DES

abbreviation for diethylstilbestrol.

DES

Abbreviation for:
deadly seven
dental environmental stress
dermal-epidermal separation
diethylstilbestrol
diffuse endocrine system
Directed Enhanced Service 
distal esophageal sphincter (US)
drug-eluting stent
dry eye syndrome

DES

Diethylstilbestrol Gynecology A synthetic estrogen more potent than natural estrogens; DES use during pregnancy was banned in 1972, as in utero exposure before the 18th gestational wk results in a 3-fold ↑ in congental abnormalities–without impairing fertility or sexual function—and vaginal wall adenosis in 35-70% of exposed ♀ infants; 0.14% of cases progress to vaginal adenocarcinoma; other DES changes include obliteration of vaginal fornices, microglandular hyperplasia of the cervix–cervical ectropion, transverse ridging–appearance, and a 2.5-fold ↑ in 1º infertility Treatment Aggressive surgery–eg, vaginectomy, hysterectomy and lymphadenectomy. See Cockscomb cervix.

DES

Abbreviation for diethylstilbestrol.

diethylstilbestrol

(di-eth?il-stil?bes'trol),

DES

A synthetic preparation possessing estrogenic properties. It is several times more potent than natural estrogens and may be given orally. It is used therapeutically in the treatment of menopausal disturbances and other disorders due to estrogen deficiencies.

CAUTION!

Diethylstilbestrol should not be administered during pregnancy. Such use has been found to be related to subsequent vaginal malignancies in the daughters of mothers who were given it.

This drug was once used extensively during pregnancy to treat threatened and habitual abortion. An estimated 5 million to 10 million Americans received DES during pregnancy or were exposed to the drug in utero. Those who were exposed to DES in utero were found to be at risk of developing reproductive tract abnormalities such as clear-cell cervicovaginal cancer in women and reproductive tract abnormalities in men. These findings were reported in 1970; the use of the drug during pregnancy was subsequently banned in the U.S. in 1971 and in Europe in 1978. Women who took the drug are now known as DES mothers and their daughters and sons are known as DES daughters and DES sons, respectively.

See: daughter, DES; DES syndrome

stent

(stent)
[Charles Thomas Stent, Brit. dentist, 1845–1901]
1. Originally, a compound used in making dental molds.
2. Any material or device used to hold tissue in place, to maintain open blood vessels, or to provide a support for a graft or anastomosis while healing is taking place.

airway stent

A tube or catheter used as a scaffold to keep an airway open. It is used, e.g., to maintain the patency of a trachea or bronchus that has collapsed as a result of compression by neighboring tissues.

bare metal stent

A vascular stent made of stainless steel or related materials. It is designed to hold an artery open with simple mechanical support. See: drug-eluting stent

covered stent

A stent whose supportive lattice is coated with biocompatible fabric or plastic, e.g., Dacron, polytetrafluoroethylene, or silicone.

drug-eluting stent

Abbreviation: DES
A stent coated with medications that it releases into surrounding intimal cells. It is designed to keep the lumen of an artery from closing both by holding the artery open and by retarding the growth of the vascular endothelium into the stent. See: bare metal stent

endoluminal stent

A stent placed inside a tubular structure or organ.

endovascular stent

A stent placed inside an artery or a vein.

esophageal stent

A tube inserted into the esophagus to open a stricture.
Enlarge picture
INSERTION OF A CORONARY ARTERY STENT: (A) A balloon catheter with a collapsed stent is advanced to the location of a coronary artery lesion. (B) The balloon is inflated, which expands the stent and compresses the lesion to increase the artery opening. (C) The balloon is then deflated and removed, leaving the expanded stent in place to prevent the artery from closing.
Enlarge picture
INSERTION OF A CORONARY ARTERY STENT: (A) A balloon catheter with a collapsed stent is advanced to the location of a coronary artery lesion. (B) The balloon is inflated, which expands the stent and compresses the lesion to increase the artery opening. (C) The balloon is then deflated and removed, leaving the expanded stent in place to prevent the artery from closing.
Enlarge picture
INSERTION OF A CORONARY ARTERY STENT: (A) A balloon catheter with a collapsed stent is advanced to the location of a coronary artery lesion. (B) The balloon is inflated, which expands the stent and compresses the lesion to increase the artery opening. (C) The balloon is then deflated and removed, leaving the expanded stent in place to prevent the artery from closing.

intraluminal coronary artery stent

A stent made of an inert material, usually metallic, with a self-expanding mesh introduced into the coronary artery. It is used to prevent lumen closure (restenosis) following bypass surgery and to treat acute vessel closure after angioplasty.
See: illustration

self-expanding stent

A stent that opens on its own after it is deployed to the lumen it is intended to occupy, e.g., a blood vessel, tube, or organ.

short stent

Spot stent.

spot stent

A stent that is deployed across a focal, severe obstruction in a lumen rather than across a longer but less extensively diseased portion it.
Synonym: short stent

urologic stent

A biologically compatible stent inserted into the ureter or urethra to relieve or prevent urinary tract obstruction. Such stents are commonly placed in the urinary tract after endoureterotomy and endopyelotomy.

drug-eluting stent

Abbreviation: DES
A stent coated with medications that it releases into surrounding intimal cells. It is designed to keep the lumen of an artery from closing both by holding the artery open and by retarding the growth of the vascular endothelium into the stent. See: bare metal stent
See also: stent

DES

See DIETHYLSTILBOESTROL.

DES

The abbreviation for diethylstilbestrol, a synthetic form of estrogen that was widely prescribed to women from 1940 to 1970 to prevent complications. It was linked to several serious birth defects and disorders of the reproductive system in daughters of women who took DES. In 1971, the FDA suggested it not be used during pregnancy and banned its use in 1979 as a growth promoter in livestock.
Mentioned in: Colposcopy

DES

Abbreviation for diethylstilbestrol.

DES

diethylstilbestrol.
References in periodicals archive ?
Since the maturation of the female reproductive tract occurs in response to estrogen, it's not surprising that DES interferes with this process.
To test whether the drug works through Wnt-7a, Sassoon and his colleagues gave DES daily to mice during days 15 to 18 of pregnancy.
While DES is no longer prescribed, DES-like drugs, such as tamoxifen, are now used to treat cancers and other illnesses.
We kept pulling up papers describing the effects of DES, either in humans or in mice.
I think Wnt-7a is probably the primary target of DES," says coauthor David A.
Although the evidence isn't as definitive, males exposed to DES in the womb may not have escaped the drug's wrath, either.
There have been profound effects on their health and there continue to be,'' said Nora Cody, executive director of the Oakland-based advocacy group DES Action.
Patti Negri, a 46-year-old Hollywood resident and DES daughter, entered a menopausal state at age 15 and was unable to have children.
People who don't have medical problems associated with DES exposure probably don't need to worry about whether their mothers took the drug.
The use of DES, sold under myriad brand names, was most widespread in the U.
Mothers who took DES have a moderate increase in the risk of breast cancer.
BPA was more potent than would be estimated from in vitro assays, although its intrinsic activity is still lower than that of DES and EP.