DEFIANT II

Doppler flow and Echocardiography in Functional cardiac Insufficiency: Assessment of Nisoldipine Therapy II. A trial assessing nisoldipine’s effect in post-MI patients on exercise duration, exercise-induced ischemia, left ventricular function by Doppler echocardiography, adverse cardiac events, and outcome(s)
Conclusion Exercise time was similar in both groups; despite improvements in physiologic parameters—e.g., prolonged time to 1 mm ST deviation, increased early peak velocity, and decreased isovolumic relaxation time—this translated to only a trend—i.e., not significant—toward lower combined endpoints—mortality and cardiac events—with nisoldipine
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The DEFIANT II is a large multicenter postinfarction study
Chairman of the DEFIANT II Steering Committee and Professor at the
DEFIANT II was a double-blind, placebo-controlled trial to