Ly75

(redirected from DEC-205)

Ly75

A gene on chromosome 2q24 that encodes a C-type lectin-domain protein which acts as an endocytic receptor, directing captured antigens from the extracellular space to a specialised antigen-processing compartment. Ly75 also downregulates B-cell proliferation.
References in periodicals archive ?
The first dendritic cell target we have studied is DEC-205 (originally called NLDC-145), an endocytic receptor expressed at high levels on dendritic cells.
Once again, delivering the HIV gag p24 through DEC-205 enhanced the immune efficacy of the protein vaccine, as measured by the percentage of gag-specific CD[4.
Christine Trumpfheller, Angela Granelli-Piperno, and Leonia Bozzacco prepared fusion antibodies to human DEC-205, MMR, and DC-SIGN and engineered them to deliver HIV gag p24.
Among the 11 patients we studied, we identified eight different gag peptides that were processed and then recognized via DEC-205.
He has engineered the DNA vaccines that are currently under testing in the field so that they have a targeting single-chain antibody to the DEC-205 receptor.
CDX-1401 is a fusion protein consisting of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 linked to the NY-ESO-1 tumor antigen.
The results from the Phase 1 study of CDX-1401 were presented in a poster session entitled, "A Phase 1 Trial of a Novel Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205 in Combination with Toll-like Receptor Agonists" at the Society for Immunotherapy Annual Meeting on Friday, October 26, 2012 by Dr.
The product consists of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 genetically linked to the NY-ESO-1 tumor antigen.
The product consists of a fully human monoclonal antibody with specificity for the dendritic cell receptor, DEC-205, genetically linked to the NY-ESO-1 tumor antigen.
This is the first DEC-205 targeted vaccine to enter clinical trials and will be combined with resiquimod (a toll-like receptor 7/8 agonist) as an adjuvant.