DDX5

DDX5

A gene on chromosome 17q21 that encodes a putatitive RNA helicase with a conserved Asp-Glu-Ala-Asp (DEAD) motif. DEAD box proteins are RNA-dependent ATPases thought to play a role in altering RNA secondary structure by translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
References in periodicals archive ?
Human tumor cells (at left, each line represents one cell) that withstood a dose of the anticancer drug cam ptothecin made more of the DDX5 enzyme (as measured by fluorescence level), while enzyme levels dropped in the cells eventually killed by the treatment.
This finding was a variant in the DDX5 gene associated with a greater than 20-fold increase in risk for Non-Alcoholic Steatohepatitis (NASH), a common progressive liver disease that often leads to fibrosis and cirrhosis.
Celera Diagnostics previously reported an association of variation in the DDX5 gene with an increased risk of fibrosis in patients infected with the hepatitis C virus at the American Association for the Study of Liver Diseases in November 2004.