DDX46

DDX46

A gene on chromosome 5q31.1 that encodes a protein with a conserved Asp-Glu-Ala-Asp (DEAD) motif. DDX46 is a putative ATP-dependent RNA helicase that plays an essential role in splicing—either before or during—A complex formation.
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We then performed quantitative RT-PCR (Q-RT-PCR) on the same samples to analyze expression for a subset of 4 randomly selected genes, KIAA0101, UBE2D3, EPAS1, and DDX46, from the list of 40 differentially upregulated genes.
Finally, DDX46 encodes a member of the DEAD box protein family that has putative helicase activity and is involved in pre-mRNA splicing as part of the 17S U2 small nuclear ribonucleoprotein complex.
Gene symbol KIAA0101 EPAS1 UBE2D3 DDX46 Fold change microarray 4.