DDX3X


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DDX3X

A gene on chromosome Xp11.3-p11.23 that encodes a protein which contains a conserved Asp-Glu-Ala-Asp (DEAD) motif and acts as an ATP-dependent RNA helicase. It interacts with hepatitis C virus core protein, changing its intracellular location, and is a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs; it is also involved in HIV-1 replication.
References in periodicals archive ?
To function properly, DDX3X must bind RNA and also release the chemical energy stored in ATP molecules.
Researchers showed that two DDX3X mutant proteins were unable to tap ATP energy.
If either of the same two mutant DDX3X proteins were substituted for the most similar protein in fission yeast, the yeast died.
Putting the mutant proteins into the yeast model identified which defects were harmful and provided insight into the DDX3X protein function," Partridge said.