VPRBP

(redirected from DDB1- and CUL4-associated factor 1)

VPRBP

A gene on chromosome 3p21.2 that encodes a protein belonging to the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.  VprBP/DCAF1 targets NF2 to the E3 ubiquitin-ligase complex for ubiquitination and proteasome-dependent degradation; it is recruited by HIV-1 Vpr after HIV-1 infection, hijacking the CUL4A-RBX1-DDB1 function, leading to arrest of the cell cycle in G2 phase and protecting the viral protein from proteasomal degradation by another E3 ubiquitin ligase.
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