DST

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DST

abbreviation for dexamethasone.

DST

A gene on chromosome 6p12.1 that encodes dystonin, a cytoskeletal linker protein which integrates intermediate filaments, actin and the microtubule cytoskeleton network, and is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional reticulum.

DST isoform 3 plays a structural role in assembling hemidesmosomes of epithelial cells; it anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes and is required for regulating keratinocyte polarity and motility; it mediates integrin ITGB4 regulation of RAC1 activity. DST isoform 6 is required for bundling actin filaments around the nucleus. DST isoform 7 regulates the organisation and stability of the microtubule network of sensory neurons to allow axonal transport.

Molecular pathology
Defects of DST cause hereditary sensory and autonomic neuropathy type 6.
References in periodicals archive ?
This year RMCGF provided 72 Mini and Micro MAX drivers from America, Mexico and Canada the opportunity to compete in a three-day invitational event, while the other 288 drivers competed in Junior MAX, 125 MAX (Senior), DD2 and DD2 Masters categories.
Summary: Al Rawahi and Pakenham-Walsh perform impressively in the DD2 finals
It was disappointment for Luke Varley who never put a foot wrong all week in the DD2 class, winning two of his heats and finishing second in the pre-final.
Tony Hogg was the top DD2 Masters driver from Team UAE with the 56th best time, followed by Hussein Umid Ali 67th and Jonathan Mowatt was 71st.
AL AIN: The most hotly contested category is the premier DD2 class where reigning World Champion, Sean Babington, holds the slenderest of leads over fierce rival and reigning UAE Champion, Piers Pakenham-Walsh, with newly-crowned Oman Champion, Sanad Al Rawahi, also in close contention.
DD2 Dundee "Clearly, thieves target urban areas where there's lots of activity to mask what they're up to - but they also favour quiet areas where they can operate with less chance of being caught in the act.
They will be racing in different age-categories including the Micro Max, Mini Max, Junior Max, Max, Max Masters and DD2.
The last round witnessed brilliant performances by Mohammed Abdulaziz who won both races in the Max Masters DD2 class with Louis Skalski finishing second in both races.
In the DD2 class Piers Pakenham Walsh, another product of the Kartdrome, ruffled up the hierarchy to claim his first victory in the highly competitive category.
She won third place in both rounds of the DD2 Bank of Beirut Karting Challenge at the inaugural Ramadan Motor Sports Festival organised by Oman Automobile Association in midA[degrees]July.
Address for correspondence: Peter Davey, Health Informatics Centre, University of Dundee Medical School, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, United Kingdom; fax: 44-1382-420-010; email: p.
The highly anticipated DD2 competition, which provided a lot of thrills, saw Oman champion Abdullah Al Rawahi taking first place.