NRAMP

(redirected from DCT1)
Also found in: Acronyms.

NRAMP

A protein of the solute carrier family 11, encoded by SLC11A1 on chromosome 2q35, which transports iron and other divalent metals (e.g., manganese, cobalt, zinc, cadmium and lead) across the apical membrane of enterocytes in the brush border of the GI mucosa and into cells by a proton-coupled process.
 
Abnormal in
Mutations of SLC11A1 have been associated with increased susceptibility to infections (e.g., tuberculosis and leprosy), and inflammatory diseases (e.g., rheumatoid arthritis and Crohn’s disease).
References in periodicals archive ?
DMT-1 Also known as DCT1, Nramp2, BMP identified as homologue of Nramp1, a protein that confers resistance to intracellular pathogens.
5] Human genes: HFE, hemochromatosis; HJV (alias, HFE2), hemochromatosis type 2 (juvenile); HAMP, hepcidin antimicrobial peptide (alias, LEAP-1); SMAD4, mothers against DPP homolog 4 (Drosophila); TfR2, transferrin receptor 2 (alias, HFE3); SLC40AI, solute carrier family 40 (iron-regulated transporter), member 1 (aliases, IREG1, FPN1, HFE4); FTL, L-ferritin; and SLCIIA2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (aliases, DMT1, DCT1, and NRAMP2).
DMT1 (9), previously called Nramp2 (6,10-13) or DCT1 (7), is a duodenal metal transporter with affinity for several divalent cations.