SAMHD1

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Also found in: Acronyms.

SAMHD1

A gene on chromosome 20pter-q12 that encodes a putative nuclease involved in the innate immune response, which acts by downregulating cell-intrinsic antiviral response. It may play a role in mediating pro-inflammatory responses to TNF-alpha signalling. It is expressed in the heart, skeletal muscle, spleen, liver and elsewhere, but not in the brain or thymus.

Molecular pathology
Defects in SAMHD1 cause Aicardi-Goutieres syndrome type 5 and chilblain lupus type 2.
References in periodicals archive ?
Referring to the report submitted by the independent UN inquiry commissionto the UN Human Rights Council (UNHRC) in Geneva on June 29 on international human rights violations committed during 2014 onslaught, DCIP highlighted the report findings noted that impunity prevails across the board for violations of international humanitarian law and international human rights law allegedly committed by Israeli forces.
I am honored to have the opportunity to continue leading DCIP," said Manzione.
The digital projection systems deployed by DCIP will comply with the technical and security specifications developed by Digital Cinema Initiatives, LLC.
This is a very exciting time in the motion picture exhibition industry," said Travis Reid, CEO of DCIP.
Addameer and DCIP expressed their outrage over the dangerous trend of excessive use of lethal force against Palestinian children.
Last year, according to the DCIP report, 561 children were killed -- 557 of them Palestinian, most as a result of Israel's Operation Protective Edge in Gaza during the summer.
According to the DCIP, Israeli forces committed grave violations against children amounting to war crimes.
A new report by DCIP (Defense for Children International-Palestine) titled Operation Protective Edge: A War Waged On Gaza's Children , displayed documented events proving that that Israel has deliberately murdered Palestinian children in its last offensive on Gaza last summer.
For children living in the Gaza Strip, 2014 was a year that brought violence, fearand loss, the DCIP said.
Powered by new Recursive Bayesian Estimation mathematics, DCIP does not require prior knowledge or rules about threats, instead using advanced mathematical modelling to detect 'unknown unknown' threats in real time.
The change in absorbance at 600 nm as DCIP reduction was measured at 30 [degrees]C for 3 min using a microplate reader.