CLEC4M

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CLEC4M

A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. The receptors are thought to recognise high-mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, among others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor then returns to the cell membrane surface, and the pathogen-derived antigens are presented to resting T cells via MHC class-II proteins to initiate the adaptive immune response.
References in periodicals archive ?
14] A DC-SIGNR is a transmembrane lectin that binds mannose residues including the glycans of ICAM3 and HIV-1 and HIV-2.
cell count, HIV VL and DC-SIGNR expression were compared using the Wilcoxon rank-sum test; proportions were compared using Fisher's exact test; and correlations were analysed using Spearman's rho.
2) while DC-SIGNR expression was seen in endothelial cells (Fig.
15] DC-SIGNR expression was detected only on capillary endothelial cells, whereas DC-SIGN was expressed only by Hobauer cells.
DC-SIGN and DC-SIGNR lectins have been shown to mediate infection in cis (cells with DC-SIGN receptors e.
22] If studies find a significant association between DC-SIGN expression and intrauterine transmission, then transplacental transmission of HIV may be retarded by the administration of DC-SIGN- and DC-SIGNR blocking molecules.
In addition, there was no association of DC-SIGN or DC-SIGNR expression with placental membrane inflammation.
Both DC-SIGN and DC-SIGNR expression were higher in placentas from HIV-positive mothers compared with HIV-negative cases, and this was statistically signiicant.
Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative north Indian individuals.
The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection.
Expression of DC-SIGN and DC-SIGNR in placentas of HIV-positive patients.
Expression of DC-SIGN and DC-SIGNRs in the placentas of HIV-positive women