CCL18

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CCL18

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL18 is chemotactic for naïve T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. It attracts naïve T cells toward dendritic cells and activated macrophages in lymph nodes, and may play a role in humoral and cell-mediated immune responses.