DAZ2

DAZ2

A gene on chromosome Yq11.223 that encodes an RNA-binding protein expressed only in premeiotic germ cells, especially in spermatogonia, which plays an essential role in spermatogenesis, possibly by binding to the 3’-UTR of mRNAs and regulating their translation. DAZ2 promotes germ cell progression to meiosis and formation of haploid germ cells, and it is a candidate for Y-chromosomal azoospermia factor. It forms a heterodimer with BOLL and DAZL, and interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.

Molecular pathology
Defects in DAZ2 cause spermatogenic failure Y-linked type 2.
References in periodicals archive ?
DAZ gene family is the most important candidate gene for male infertility in this region and consists of four functional copies including DAZ1, DAZ2, DAZ3 and DAZ4 arranged in two clusters (18,23).