DAX1


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DAX1

A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.

Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
References in periodicals archive ?
IL1RAPL1 Is Associated with Mental Retardation in Patients with Complex Glycerol Kinase Deficiency Who Have Deletions Extending Telomeric of DAX1.
Adrenocorticotropin-dependent precocious puberty of testicular origin in a boy with X-linked adrenal hypoplasia congenita due to a novel mutation in the DAX1 gone.
Double auction experiments: DA1 = 3pd209, DA2 = 3pd210, DAX1 = 3pd255, DAX2 = 3pd256.