DAT


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DAT

Abbreviation for dopamine transporter.

DAT

Abbreviation for:
daunomycin, Ara-C (cytarabine), 6 thioguanine
days after treatment
delayed-action tablet
dementia of Alzheimer’s type
Dental Admission Test
digital audio tape (Medspeak-UK)
direct agglutination test
direct antibody testing
direct antiglobulin test
Disability Appeal Tribunal (obsolete) (Medspeak-UK)
Disaster Action Team
Drug Action Team (Medspeak-UK)

DAT

Direct antiglobulin test, see Antiglobulin test.

antiglobulin test

A test for the presence in human blood of antibodies. The antibodies present in the blood do not, themselves, cause agglutination. It is the addition of an antibody made in animals (antiglobulin) that stimulates red blood cell clumping. The direct antiglobulin test (DAT) is used to diagnose autoimmune hemolytic anemia and hemolytic disease of the newborn. The indirect antiglobulin test (IAT), or Coombs' test, is used to identify blood types. Synonym: Coombs' test

direct antiglobulin test

Abbreviation: DAT
A laboratory test for the presence of complement or an antibody that is bound to a patient's red blood cells (RBCs). The test is used in patients with autoimmune hemolytic anemia, hemolytic disease of the newborn, and transfusion reactions. After the patient's RBCs are washed to remove unbound antibodies, they are mixed with antihuman globulin serum containing polyvalent antibodies that bind with the antibody or complement on the RBCs and cause them to agglutinate (clump). Monoclonal antibodies can be used to identify the specific class of antibody or complement component causing RBC destruction. See: Coombs' test

direct antiglobulin test

Abbreviation: DAT
A laboratory test for the presence of complement or an antibody that is bound to a patient's red blood cells (RBCs). The test is used in patients with autoimmune hemolytic anemia, hemolytic disease of the newborn, and transfusion reactions. After the patient's RBCs are washed to remove unbound antibodies, they are mixed with antihuman globulin serum containing polyvalent antibodies that bind with the antibody or complement on the RBCs and cause them to agglutinate (clump). Monoclonal antibodies can be used to identify the specific class of antibody or complement component causing RBC destruction. See: Coombs' test

dementia

(di-men'cha) [L. dementia, madness]
A progressive, irreversible decline in mental function, marked by memory impairment and, often, deficits in reasoning, judgment, abstract thought, registration, comprehension, learning, task execution, and use of language. The cognitive impairments diminish a person's social, occupational, and intellectual abilities. In the U.S., 4.5 million people are afflicted by dementia. The prevalence is esp. high in the very elderly: about 20% to 40% of those over 85 are demented. Dementia is somewhat more common in women than in men. It must be distinguished by careful clinical examination from delirium, psychosis, depression, and the effects of medications. See: Alzheimer disease; Huntington chorea; Parkinson disease; table

Symptoms

The onset of primary dementia may be slow, taking months or years. Memory deficits, impaired abstract thinking, poor judgment, and clouding of consciousness and orientation are not present until the terminal stages; depression, agitation, sleeplessness, and paranoid ideation may be present. Patients become dependent for activities of daily living and typically die from complications of immobility in the terminal stage.

Etiology

Dementia may result from many illnesses, including AIDS, chronic alcoholism, Alzheimer disease, vitamin B12 deficiency, carbon monoxide poisoning, cerebral anoxia, hypothyroidism, subdural hematoma, or multiple brain infarcts (vascular dementia).

Treatment

Some medications, e.g., donepezil, nemantidine, and tacrine, improve cognitive function in some patients.

Patient care

Demented patients deserve respectful and dignified care at all stages of their disease. Caregivers assist the demented with activities of daily living and with the cognitive and behavioral changes that accompany the disease. A variety of nursing interventions may reduce the risk of inadvertently precipitating behavioral symptoms. Health care professionals should reinforce the patient's abilities and successes rather than disabilities and failures. Caregivers can help the patient make optimal use of his or her abilities by reducing the adverse effects of other health conditions, sensory impairments, and cognitive defects while maximizing social and environmental factors that support functional capacity. Daily routines should be adjusted to focus on the person rather than the task, e.g., the comfort of bathing rather than the perceived need to bathe in a certain way at a certain time.

Interaction and communication strategies should be adjusted to ensure that the message delivered is the one perceived (obtain attention, make eye contact, speak directly to the individual, match nonverbal communication and gestures to the message, slow the pace of speech, use declarative sentences, use nouns instead of pronouns). Commands including the word “don’t” and questions beginning with “why” should be avoided. Tasks should be broken down into manageable steps. Reassurance and encouragement are provided to assist the patient to act more independently. Reality grounding is not necessary for such a patient; thus, if the patient asks to see his mother (who is dead), reminding him of her death may reinforce the pain of that loss. It may be better to redirect the conversation, asking the patient to talk about his mother, instead. Written agreements and reminders may not be as useful as they would be in the care of other patients, for a demented patient may not remember what has been negotiated and agreed upon in the past. The patient’s environment should be adjusted to provide needed safety. Finding the correct balance between doing too much or too little may be difficult for the caregiver, who should recognize that the balance may shift day to day and that patience and flexibility are more helpful. Caregivers must be aware that the patient will have moments of lucidity, which should be treasured but not considered evidence that the patient is exaggerating or feigning his or her disease to obtain attention. Family members who provide care must be aware that they, too, have emotional needs and can become angry, frustrated, and impatient and that they need help to learn to forgive themselves as well as the loved one they are caring for. Finally, such caregivers must learn how to accept help and should not fear to admit that they cannot carry the burden of care by themselves.

AIDS-dementia complex

See: AIDS-dementia complex

alcoholic dementia

A form of toxic dementia in which there is loss of memory and problem-solving ability after many years of alcohol abuse.

dementia of the Alzheimer type

Abbreviation: DAT
See: Alzheimer disease

apoplectic dementia

Sudden loss of cognitive or intellectual function as a result of a large or bloody stroke or a brain tumor.

Binswanger dementia

Binswanger disease.

dialysis dementia

A neurological disturbance in patients who have been on dialysis for several years. There are speech difficulties, myoclonus, dementia, seizures, and, eventually, death. The causative agent is presumed to be aluminum in the dialysate.

epileptic dementia

An infrequent complication of epilepsy, presumed to result from injury to neurons during uncontrolled seizures.

frontotemporal dementia

A general term for any of four types of dementia: 1. frontotemporal lobar degeneration; 2. Pick’s disease; 3. primary progressive aphasia; or 4. semantic dementia. Symptoms include personality changes, apathy, compulsive or repetitive behavior, lack of social inhibition, and deterioration in language use.

Heller dementia

Regressive autism.

HIV-associated dementia

See: AIDS-dementia complex

dementia with Lewy bodies

A common neurodegenerative disease characterized by gradual and progressive loss of intellectual abilities combined with a movement disorder that resembles Parkinson disease. Those affected often have marked fluctuations in their ability to stay alert and awake and also visual hallucinations. The disease is characterized pathologically by deposits of Lewy bodies. The dementia is treated symptomatically.

mixed dementia

Dementia in which elements of both Alzheimer disease and vascular dementia are found.

multi-infarct dementia

Dementia resulting from multiple small strokes. After Alzheimer disease, it is the most common form of dementia in the U.S. It has a distinctive natural history. Unlike Alzheimer disease, which develops insidiously, the cognitive deficits of multi-infarct dementia appear suddenly, in stepwise fashion. The disease is rare before middle age and is most common in patients with hypertension, diabetes mellitus, or other risk factors for generalized atherosclerosis. Brain imaging in patients with this form of dementia shows multiple lacunar infarctions. Synonym: vascular dementia

paralytic dementia

An obsolete term for tertiary syphilis.

dementia paralytica

An obsolete term for tertiary syphilis.

postfebrile dementia

Dementia following a severe febrile illness.

presenile dementia

Dementia beginning in middle age, usually resulting from cerebral arteriosclerosis or Alzheimer disease. The symptoms are apathy, loss of memory, and disturbances of speech and gait.

primary dementia

Dementia associated with Alzheimer disease.

dementia pugilistica

Traumatic dementia, i.e., encephalopathy or an organic brain syndrome caused by closed head injury. It is sometimes referred to colloquially as “boxer's brain.”

semantic dementia

Any of a group of brain disorders marked by nearly complete losses in the understanding of word meanings, spelling, and the identification or recognition of facts, faces, or objects. The disease is marked pathologically by local atrophy in the neocortex of the temporal lobe of the brain.

senile dementia of the Alzheimer type

Abbreviation: SDAT
Alzheimer disease.

subcortical vascular dementia

Binswanger disease.

syphilitic dementia

Dementia caused by tertiary syphilis.

toxic dementia

Dementia caused by exposure to neurotoxins such as lead, mercury, arsenic, alcohol, or cocaine.

vascular dementia

Abbreviation: VaD
Multi-infarct dementia.
AgePrevalence
< 600.1%
60–64~1%
> 653 — 11%
> 8525 — 47%
References in periodicals archive ?
Founded in 1978, DAT Solutions LLC is a wholly owned subsidiary of Roper Technologies, a diversified technology company and constituent of the S&P 500, Fortune 1000 and Russell 1000 indices.
From the outset, the commission sent a strong and consistent message of support for the DAT process; however, technical and community team members initially had mixed feelings.
The driving forces for DAT have been economics and convenience.
Businesses rely on the volume-leading DAT format to back up and restore critical business data.
Practically, you would not want to bring a panic because of this, but there are implications to a positive DAT," she said, urging additional studies to confirm the finding and determine whether DAT testing could help detect early cancers in healthy people.
Test Performance The researchers found that lower DAT levels corresponded to worse performance on all four motor and memory tests described above.
Maxell Corporation of America, a provider of premium data storage media products, announced on Friday (27 April) general availability starting in May of DAT 160, the sixth generation DDS media.
In April, the TransCore DAT North American Freight Index achieved the highest volume in a single month since the Index was established in 1996.
8, 2015 /PRNewswire/ -- DAT Solutions has launched a new online analytics service for transportation and logistics professionals to access truck and load data on the 149 key market areas in North America with the highest concentrations of inbound and outbound freight.
They don't really shine; they have been a disappointment for DAT.
BoNT/C also demonstrated a dose dependent reduction of DAT phosphorylation to 84% of the basal level with a 10 ng/ml dose of BoNT/C, while increased doses further reduced DAT phosphorylation to 70% of basal.
In this study we investigated if PKC-dependent DAT phosphorylation and transport activity were affected by acute exposure of dopamine or the transport blockers such as cocaine, mazindol, GBR12909, or the cocaine analog CFT.