DALM


Also found in: Acronyms.

DALM

Dysplasia-associated lesion/mass GI disease An acronym referring to ↑ incidence of colorectal CA with ulcerative colitis when the pathologist finds dysplasia and the endoscopist finds a tumor mass; DALM alone may be a sufficient criterion for performing a proctocolectomy
References in periodicals archive ?
Furthermore, the combination of p53, Ki-67, and [beta]-catenin could be a practical immunohistochemical panel to help distinguish DALM lesions from sporadic tubular adenomas.
In their study, 49% of patients had an adenoma-like DALM and 51% had sporadic adenomas.
With better screening modalities such as chromoendoscopy, detection and characterization of dysplastic lesions, including flat and DALM dysplasia, IBD-associated serrated lesions, and "field cancerization," we will improve our understanding of and approach to risk stratification.
Adenomas and adenoma-like DALMs in chronic ulcerative colitis: a clinical, pathological, and molecular review.
In fact, a recent British study with confocal microscopy (82) has claimed 97% accuracy in discriminating between DALMs and adenoma-like polyps.
Histologic comparisons of individual morphologic features in DALMs and adenoma-like dysplastic polyps have indicated that DALMs show increased architectural disarray, (83) villous architecture, and inflammation, (74) but these criteria have not been evaluated longitudinally and have so far lacked the statistical power to guide the management of patients with raised dysplasia.
In the study reported today at DALM, Isis demonstrated that apoB inhibition led to compensatory changes in liver fat metabolism including reduced fat production and increased fat breakdown.
In each of the studies presented at DALM, all treatments were well tolerated, with similar adverse event types and occurrence rates among treatment groups.