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D4 receptor |
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D4 receptor Neurology A receptor present on GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, globus pallidus, and substantia nigra–pars reticulata; D4R is of clinical interest
given its high affinity for clozapine, an atypical neuroleptic agent, which ↓ the positive and negative symptoms in acutely psychotic and treatment-resistant schizophrenics, without producing extrapyramidal signs; a recent report suggests that
this effect may be due to D4R-mediated GABA modulation through disinhibition of excitatory transmission in intrinsic cortical, thalamocortical, and extrapyramidal pathways How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| The D4 receptor gene associated with ADHD is important because of its association with the blunted response to norepinephrine and dopamine. Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. He screened his own dopamine D4 receptor gene, he said, to see if he had the 7-repeat version of it, but found he did not. |
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