D4 receptor

D4 receptor

Neurology A receptor present on GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, globus pallidus, and substantia nigra–pars reticulata; D4R is of clinical interest given its high affinity for clozapine, an atypical neuroleptic agent, which ↓ the positive and negative symptoms in acutely psychotic and treatment-resistant schizophrenics, without producing extrapyramidal signs; a recent report suggests that this effect may be due to D4R-mediated GABA modulation through disinhibition of excitatory transmission in intrinsic cortical, thalamocortical, and extrapyramidal pathways
References in periodicals archive ?
Dopamine D4 Receptor * Kappa Opioid Receptor * Galanin
Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility.
We are the only group that knows, through our experimental work, what the D4 receptor does, which activation causes decreased motor activity, because it would be acting in this special kernel that controls attention and partly motor activity'" Aceves Ruiz said.
Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking.
Leukotriene D4 receptor antagonist montelukast alleviates protamine sulphate-induced changes in rat urinary bladder.
Building on previous research, the team focused on the dopamine D4 receptor, which has been linked to a variety of behavioural disorders, but never proven useful in treatment.
Here's an actual example: "The variable number tandem repeats (VNTR) polymorphism in exon III of the human dopamine D4 receptor gene (DRD4) has been correlated with an array of behavioral phenotypes.
Emanuele and colleagues (2007) looked for associations between markers in neurotransmitter genes (the serotonin transporter gene, 5-HTT; the serotonin receptor 2A, 5HT2A; the DA D2 receptor gene, DRD2; and the DA D4 receptor gene, DRD4) and the six styles of love (eros, ludus, storge, pragma, mania, and agape).
Phahmacology of Montelukast sodium (Singulair), a potent a selective leukotriene D4 receptor antag onist.
In a separate study, other ADHD researchers found that a variant in the dopamine D4 receptor (DRD4) gene, which is widely associated with the disorder, correlated with differences in cortical thickness in regions of the brain involved in controlling attention.
Linkage analysis and molecular haplotyping of the dopamine D4 receptor gene promoter region.