D4 receptor

0.01 sec.

D₄ receptor

Neurology A receptor present on GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, globus pallidus, and substantia nigra–pars reticulata; D₄R is of clinical interest given its high affinity for clozapine, an atypical neuroleptic agent, which ↓ the positive and negative symptoms in acutely psychotic and treatment-resistant schizophrenics, without producing extrapyramidal signs; a recent report suggests that this effect may be due to D₄R-mediated GABA modulation through disinhibition of excitatory transmission in intrinsic cortical, thalamocortical, and extrapyramidal pathways

Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.

?Page tools

Printer friendly
Cite / link

Feedback
Add definition

Mentioned in	?		References in periodicals archive	?		Medical browser	?		Full browser	?
No references found			In a separate study, other ADHD researchers found that a variant in the dopamine D4 receptor (DRD4) gene, which is widely associated with the disorder, correlated with differences in cortical thickness in regions of the brain involved in controlling attention. PET scans show depressed dopamine activity in ADHD by Moon, Mary Ann / Clinical Psychiatry News When the results were compared, scientists found sexual responses were linked to the D4 receptor gene. THE RANDY GENE; Scientists find excuse Casanovas have been praying for by Daily Record (Glasgow, Scotland) They also found a link between a variant in the dopamine D4 receptor and the likelihood of someone taking risks with their health. SMOKING, DRINKING, DOING DRUGS? BLAME YOUR GENES by The Mirror (London, England)			D&E D&X d, D d- d-amino acid oxidase D-dimer D-dimer test d-glucose d-isomer D-lactic acidosis D-limonene D-loop d-lysergic acid diethyl-amide d-penicillamine D-phenylalanine D-Val D. D.D.S D.H.E.-45 D.M.D D.O D.P.H D.P.M D.V.M D/C D4 receptor d4T DA Da Costa syndrome Da Vinci da Vinci surgical system daboia DAC dacarbazine Dacelo novaeguineae Dachau Hypothermia Experiments Dachshund daclizumab Dacogen DaCosta's syndrome dacrocystitis dacrocystorhinotomy Dacron Dacron cuff dacry(o)- dacry- dacryadenitis dacryagogue dacryo- dacryoadenalgia dacryoadenectomy			D2T2 D2T3 D2U D2V D2VISP D2X D3 D3 D3 Dopamine Receptor D3-brane D30 D37 D3A D3D D3D D3DRM D3E D3G D3LOC D3LS D3M D3R D3T D3V D4 D4 D4 Dopamine Receptor D4 receptor D4-brane D4-D D4-TMP D4A D4B D4C D4D D4DR D4E D4H D4J D4K D4L D4LC D4LD D4M D4MD D4P D4R D4S D4S D4t D4t D4Td D4X D5 D5

Medical Dictionary

Free Tools:	For surfers: Free toolbar & extensions \| Word of the Day \| Help For webmasters: Free content \| Linking \| Lookup box \| Double-click lookup

Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.