D4 receptor

D4 receptor

Neurology A receptor present on GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, globus pallidus, and substantia nigra–pars reticulata; D4R is of clinical interest given its high affinity for clozapine, an atypical neuroleptic agent, which ↓ the positive and negative symptoms in acutely psychotic and treatment-resistant schizophrenics, without producing extrapyramidal signs; a recent report suggests that this effect may be due to D4R-mediated GABA modulation through disinhibition of excitatory transmission in intrinsic cortical, thalamocortical, and extrapyramidal pathways
References in periodicals archive ?
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking.
Building on previous research, the team focused on the dopamine D4 receptor, which has been linked to a variety of behavioural disorders, but never proven useful in treatment.
Here's an actual example: "The variable number tandem repeats (VNTR) polymorphism in exon III of the human dopamine D4 receptor gene (DRD4) has been correlated with an array of behavioral phenotypes.
Emanuele and colleagues (2007) looked for associations between markers in neurotransmitter genes (the serotonin transporter gene, 5-HTT; the serotonin receptor 2A, 5HT2A; the DA D2 receptor gene, DRD2; and the DA D4 receptor gene, DRD4) and the six styles of love (eros, ludus, storge, pragma, mania, and agape).
Analysis of dopamine D4 receptor gene polymorphism using microchip electrophoresis.
When the results were compared, scientists found sexual responses were linked to the D4 receptor gene.
When the results were compared, scientists found sexual responses correlated with variants of the D4 receptor gene.
They also found a link between a variant in the dopamine D4 receptor and the likelihood of someone taking risks with their health.
We have developed a laboratory experiment in which students purify their own DNA and examine polymorphisms in the Dopamine D4 receptor gene.
Structural and functional characteristics of the dopamine D4 receptor.
Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma.
In both cases, the scientists searched for an association between a taste for the novel and a particular variant in the so-called dopamine D4 receptor gene.