dihydroergotamine mesylate(redirected from D.H.E. 45)
[dīhī′drō·ərgot′əmēn me′si lāt]
an ergot alkaloid causing vasoconstriction through stimulation of several types of receptors, including alpha-adrenergic receptors and serotonin receptors.
indications It is prescribed for the treatment of migraine and vascular headache.
contraindications Cardiovascular disease, hypertension, liver or kidney dysfunction, sepsis, pregnancy, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are gangrene and the toxicity of the ergot alkaloids.
MigranalA nasal spray formulation of an ergot compound used to manage migraines, but not hemiplegic or basilar migraines and not as prophylaxis.
Rarely: cardiac events, including coronary artery vasospasm, transient myocardial ischaemia or infarction, ventricular tachycardia and ventricular fibrillation. More commonly: burning sensation, dysgeusia, diarrhoea, dizziness, drowsiness, dry mouth, hot flushes, irritation, nasal congestion or dryness, nasal discharge, nausea, sinusitis, sore throat, exhaustion, weakness.
A vasoconstrictor used in treating migraine.