AKAP10

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AKAP10

A gene on chromosome 17p11.1 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of protein kinase A (PKA), confining the enzyme to discrete locations within the cell based on different targeting motifs. AKAP10 binds to both RI- and RII-alpha subunits of PKA; it also has an RGS (regulator of G protein-signalling) domain and thus might interact with G-alpha proteins, providing a link between the signalling machinery and the downstream kinase.
References in periodicals archive ?
From the Company's population genetics data, SEQUENOM extrapolates that an estimated 50 million individuals in the United States are carriers of a genetic variation in D-AKAP2 that exposes them to health risks, and of those an estimated 25 million will actually become sick.
Except for the historical information contained herein, the matters set forth in this press release, including statements relating to completion of the Company's genetic discovery program, the effects of efficiency improvements, cash usage and balances, MassARRAY usage rates, the effects of carrying D-AKAP2, and the availability of the SNP assay portfolio to the mouse genetics community, are forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995.