d-dimer

(redirected from D dimer)

dimer

 
1. a compound formed by combination of two identical simpler molecules.
2. a capsomer having two structural subunits.
D-dimer a fragment of fibrin that is formed as a result of fibrin degradation. A positive test for its presence in the blood is suggestive of conditions such as thrombotic disease, sickle cell crisis, malignancy, disseminated intravascular coagulation, or recent surgery.

d-dimer

a dimer byproduct resulting from fibrinolysis; produced by cross linkage of d-domain fibrin monomers by activated factor XIII, fibrin stabilizing factor; present in low levels in normal animals, but found at particularly high levels in association with thrombotic and hemostatic disorders; assayed as an adjunctive diagnostic tool in conditions such as malignant neoplasia, infectious disease, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, hyperadrenocorticism, pulmonary thromboembolism, and disseminated intravascular coagulation or DIC. d-dimer production requires both plasmin and thrombin activation. Note that generation of fibrin/fibrinogen degradation products (FDPs) requires only plasmin action on fibrin or fibrinogen. d-dimers clear through urinary excretion, so assay may show falsely increased levels during renal dysfunction. Laboratory ELISA measurement can identify fibrinolysis.

d-dimer

Hematology A fibrin split product that can be used in a sensitive assay of plasmin activity, which is often ↑ in systemic consumptive coagulopathy, ie DIC. See Disseminated intravascular coagulation, Fibrin split products.

d-dimer

A covalently cross-linked degradation product released from the cross-linked fibrin polymer during plasmin-mediated fibrinolysis. Laboratory measurements of this product are made using latex bead assay, or enzyme-linked immunosorbent assay can be used to identify the presence of fibrinolysis; helpful in diagnosis of deep vein thrombosis.

d-dimer

(dī'mer)
A covalently cross-linked degradation product released from the cross-linked fibrin polymer during plasmin-mediated fibrinolysis. Laboratory measurements of this product are made using latex bead assay, or enzyme-linked immunosorbent assay, and can be used to identify the presence of fibrinolysis; helpful in diagnosis of deep vein thrombosis.
References in periodicals archive ?
75% (n = 25/33) of patients with involved lymph nodes had elevated D dimer, which is comparable with our study.
Diaz Nuevo, "Diagnostic value of D dimer in pulmonary embolism and pneumonia," Respiration, vol.
Validation, calibration, and specificity of quantitative D dimer assays.
Pooled patient samples as reference material for D dimer.
An immunoassay for human D dimer using monoclonal antibodies.
I use them as they validate the conclusions of the College of Emergency Room Physicians (Table II-IV) and point out the utility of the d dimer assays.
In certain conditions, normal D dimers levels in plasma almost rule out the occurrence of any thromboembolic disease8,9.
The patient having D dimers value more and less than 500 ug/L were considered as positive and negative cases respectively.
D dimers assay analyses revealed 90% (27 patients) as positive and 10% (3 patients) as negative (Figure 3).