cytotoxicity

(redirected from Cytoxicity)
Also found in: Dictionary, Thesaurus.

cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cytotoxicity

/cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.

cytotoxicity (sī´tōtoksis´itē),

n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells.

cytotoxicity

destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC).
References in periodicals archive ?
Eucryphin did not cause the cytoxicity against THP-1 monocytes and THP-1 macrophages (data not shown).
For the cytoxicity determination cells were seeded into 96-well plates (100 [micro]l/well at a density of 1 x [10.
The cytoxicity assays were carried out in eight separate experiments, whereas the apoptosis induction evaluation was conducted in quadruplicate.
a privately held oncology company, today announced the presentation of positive results in tests of cytoxicity and inhibition of pan-cell cycle progression using Alchemix, the Company's novel alkylating anthraquinone, in a poster session at the 16th International Prostate Cancer Update Conference, Beaver Creek, Colorado.
Simultaneously, another class of compound extracted and isolated from the Goniothalamus, styryl lactones, also showed strong cytoxicity.
Poster Number: G16 Abstract No: 2567 Conclusion: Treatment with IL-21 increased the activity of mononuclear cells in trastuzumab-mediated ex vivo antibody dependent cell mediated cytoxicity (ADCC) assays.
morrisonicola Hay, show anti-oxidant activity or cytoxicity against leukemia cell line U937.
Antimicrobial activity and cytoxicity of Zanthoxylum budrunga.
Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytoxicity induced by tert-butylhydroperoxide via an ironchelating mechanism.
Table 1 Cytoxicity profiles of methanol extracts from Himenocardia acida, Mangifera indica and Sida rhombifolia against ovarian neoplasia.
This assay is widely used as a preliminary screen to quantify cell proliferation, viability, cytoxicity and sensitivity (Mosmann, 1983; Fokkema et al.
Jung NP, Yoon SK, Ryu SY (1999) P-glycoprotein (Pgp) does not affect the cytoxicity of flavonoids from Sophora flavescens, which also have no effects on Pgp action.