cytotoxicity

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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cytotoxicity

/cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.

cytotoxicity (sī´tōtoksis´itē),

n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells.

cytotoxicity

destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC).
References in periodicals archive ?
Antibody-dependent cell-mediated cytoxicity (ADCC) increased 150-fold relative to the non Fc-engineered version and was found to be superior to that of rituximab.
Oxygen requirement for near-UV mediated cytoxicity of [alpha]-terthienyl to Escherichia coli and Saccharomyces cerevisiae.
Cytoxicity of a putative toxin from the Pfiesteria piscicida dinoflagellate [Abstract].
Preliminary results reported in this grant demonstrated that specific polypeptide doxorubicin conjugates showed increased cytoxicity and decreased toxicity when used in conjunction with hyperthermia.
Furthermore, eucryphin did not cause the cytoxicity against human keratinocytes (data not shown).
The enormous advantage that drug research can enjoy would be the availability of functional readouts by cataloguing the cellular activity profiles in every well, thus reporting the cytoxicity, potency for a compound's behaviour against the target.
Increased GSH level is the first line of defense in radiation cytoxicity, which detoxifies and eliminates free radicals and electrophilic compounds from the cell (Souba et al.
a privately held oncology company, today announced the presentation of positive results in tests of cytoxicity and inhibition of pan-cell cycle progression using Alchemix, the Company's novel alkylating anthraquinone, in a poster session at the 16th International Prostate Cancer Update Conference, Beaver Creek, Colorado.
For the cytoxicity determination cells were seeded into 96-well plates (100 [micro]l/well at a density of 1 x [10.
Poster Number: G16 Abstract No: 2567 Conclusion: Treatment with IL-21 increased the activity of mononuclear cells in trastuzumab-mediated ex vivo antibody dependent cell mediated cytoxicity (ADCC) assays.
Simultaneously, another class of compound extracted and isolated from the Goniothalamus, styryl lactones, also showed strong cytoxicity.
morrisonicola Hay, show anti-oxidant activity or cytoxicity against leukemia cell line U937.