cytotoxicity

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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cytotoxicity

/cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.

cytotoxicity (sī´tōtoksis´itē),

n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells.

cytotoxicity

destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC).
References in periodicals archive ?
The unique design of the selectively cleavable linker connecting the antibody to the duocarmycin drug leads to high stability in circulation, and induces efficient release of the cytotoxin in the tumor.
22) The kind of cell death induced by the pure cytotoxin was verified by flux cytometry analysis assay (annexin V-FITC Apoptosis Detection Kit I; BD Biosciences Pharmingen).
Cobra cytotoxins and cardiotoxins may also disturb different cell types (Rahmy 2001).
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model.
Specific for cancer, mutated IL-13s are envisioned to carry cytotoxins or radiation energy to these cancers.
pneumoniae isolates, their genotypes, and their phenotypes (their ability to bind to cultured HEp-2 cells and to promote cytoskeleton modifications [fluorescent actin staining test], to invade epithelial cells, to produce various enterotoxins and cytotoxins, and to induce fluid accumulation in the intestines of newborn mice).
Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
com/report/antibody-drug-conjugate-market Market Insights Antibody Drug Conjugates are monoclonal antibodies that are attached to biologically active drugs such as chemotherapeutic drugs, radioactive isotopes, cytokines or cytotoxins via chemical linkers with liable bonds.
PCM-075 has demonstrated synergy in preclinical studies with over 10 chemotherapeutic and target agents used in hematologic and solid tumor cancers, including FLT3 and HDAC inhibitors, taxanes, and cytotoxins.
Upon internalisation of the ADC, the antibody-bound cytotoxins are released intracellularly, leading to programmed tumor cell death.
difficile infects the human gut and releases enterotoxins and cytotoxins, causing severe diarrhea and inflammation.
Lichtenstein, however has warned against the use of cytotoxins and radioactive isotopes in the acute disseminated disease for fear of further injury to an already damaged bone marrow.