cytotoxicity

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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cytotoxicity

/cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.

cytotoxicity (sī´tōtoksis´itē),

n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells.

cytotoxicity

destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC).
References in periodicals archive ?
Overexpressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy.
Debinski stated, "It is satisfying to see the progress on this first generation of targeted cytotoxins that underlines clinically the validity of the target in brain tumors.
However, recent findings suggest that the concerted actions of several cytotoxins, including the bi-component leukocidins, also play important roles in staphylococcal pathogenesis.
Production of enterotoxin and cytotoxin in Campylobacterjejuni strains isolated in Costa Rica.
This is done by analysing - Products currently available in the market and those under development (both clinical / pre-clinical), - Technology providers, and key cytotoxin, linker and conjugation technologies supporting the development of improved ADCs, - Partnerships which have taken place over the last five years covering product co-development, technology licensing and co-marketing, - Competitive landscape and inherent threats to growth in the short and long term, - Development and sales potential based on target consumer segments, likely adoption rate and expected pricing.
In view of the structural similarities between NOS and P450 reductase, these have been investigated for the capacity of NOS to reduce the hypoxic cytotoxin tirapazamine, the anti-tumour agent doxorubicin, and also the redox cycling compound menadione.
The Traditional Treatments: Naked Antibody and Cytotoxins 3.
The cytotoxin is a potent bacterially derived Pseudomonas Exotoxin (PE) toxic to human cells.
Cytotoxins are of crucial importance for the effectiveness of the ADC.
These ligand targeted cytotoxins are potentially useful in a broad variety of cancers.
There are limited number of contract manufacturers with capabilities for development of linkers and cytotoxins.
Through the use of these high containment isolators, our scientists create and maintain a controlled sterile envelope that enables us to safely process potent drug classes including cytotoxic antibody drug conjugates, cytotoxins, steroids, hormones and acutely toxic substances.