Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in multiple sclerosis patients resulted in the in vivo induction of CD8+ cytotoxic T-cells
and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
When cancerous tumors express PD-L1, however, they are able to escape detection and destruction by cytotoxic T-cells
-- a type of cancer-killing immune cell -- allowing the tumor to survive and grow.
AST-VAC1 is injected into the patient's skin; and from there the dendritic cells travel to the lymph nodes and instruct cytotoxic T-cells
(T-cells that "kill" other cells) to kill tumor cells that express telomerase on their surface.
When administered as a therapeutic, the bispecific immune cell engager brings cytotoxic T-cells
in contact with the target cancer cell where the cytotoxic T-cell
kills the cancer cell.
In vitro studies have demonstrated that autologous dendritic cells transfected with hTERT mRNA stimulate hTERT-specific cytotoxic T-cells
(CTL) from the peripheral blood of patients with cancer.
BiTE molecules are part of a novel class of antibody derivatives with the potential to selectively direct and activate an individual's cytotoxic T-cells
, the body's most potent killer cells, to act against cancer cells.
The study conducted by Chen and coworkers, indicated that T-cell vaccination with autologous selected synovial T-cells in rheumatoid arthritis patients resulted in the induction of CD4+ Tregs and CD8+ cytotoxic T-cells
specific for T-cell vaccine.
Another key 2006 BioScapes Competition winner is a striking video depicting what has been described as the first-ever visualization of cytotoxic T-Cells
zeroing in on target cells and killing them.
This novel cytokine has potent biological activity in regulating key classes of immune cells, including cytotoxic T-cells
and NK cells, which are thought to play key roles in eliminating malignant and infected cells from the body.
The secondary objective is to determine the immunogenicity of the vaccine or the level of the immune response as measured by the quantity and breadth of cytotoxic T-cells