cytotoxic T cell

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cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids.
Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
Data in murine models show that cytotoxic T lymphocytes (CTL) can kill malignant cells that express WT1 with a high degree of safety.
That publication, as well as subsequent research, demonstrated that the RNA encoding the catalytic reverse transcriptase protein component of human telomerase (hTERT RNA), when introduced into dendritic cells, can stimulate the immune system to produce cytotoxic T lymphocytes (CTLs, or killer-T cells) capable of recognizing and destroying telomerase-positive cancer cells.
Upon immunization, the TERT RNA-modified dendritic cells educate specialized killer cells known as cytotoxic T lymphocytes (CTLs) to recognize and destroy cancer cells expressing telomerase.
5,662,907 entitled, "Induction Of Anti Tumor Cytotoxic T Lymphocytes In Humans Using Synthetic Peptide Epitopes.
The second component of the UBI(R) prostate cancer immunotherapy program is targeted specifically at treating androgen-independent prostate cancer, and aims to induce cytotoxic T lymphocytes (CTL) capable of destroying the remaining tumor burden of androgen-independent tumor cells, which fail to respond to LHRH androgen-dependent immunotherapy.
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