Functionally inert HIV-specific cytotoxic T lymphocytes
do not play a major role in chronically infected adults and children.
Memory and distribution of virus-specific cytotoxic T lymphocytes
(CTLs) and CTL precursors after rotavirus infection.
are studying the action of cytotoxic T lymphocytes
, cellular immune responders that attack foreign or infected cells.
Data in murine models show that cytotoxic T lymphocytes
(CTL) can kill malignant cells that express WT1 with a high degree of safety.
The article, entitled "Dendritic Cells Transduced with Full-Length Wild-Type p53 Generate Antitumor Cytotoxic T Lymphocytes
from Peripheral Blood of Cancer Patients," indicated that dendritic cells treated with INGN 201 were able to induce a specific antitumor immune response mediated by cytotoxic T lymphocytes
, or killer T cells.
That publication, as well as subsequent research, demonstrated that the RNA encoding the catalytic reverse transcriptase protein component of human telomerase (hTERT RNA), when introduced into dendritic cells, can stimulate the immune system to produce cytotoxic T lymphocytes
(CTLs, or killer-T cells) capable of recognizing and destroying telomerase-positive cancer cells.
Responses such as T cell proliferation (replication of white blood cells in laboratory tests), the production of interferon (produced by lymphocytes in response to a viral infection) and the production of cytotoxic T lymphocytes
(killer T cells) were induced by the vaccine.
Upon immunization, the TERT RNA-modified dendritic cells educate specialized killer cells known as cytotoxic T lymphocytes
(CTLs) to recognize and destroy cancer cells expressing telomerase.
Most importantly, cytotoxic T lymphocytes
were produced following vaccination.