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cytotoxic T lymphocyte

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
cytotoxic
having a deleterious effect upon cells.

cytotoxic antibody
see cytotoxic antibody.
cytotoxic drugs
generally refers to those used in chemotherapy of neoplasms, e.g. cyclophosphamide, vincristine, etc.
cytotoxic T lymphocyte
see T lymphocyte.

cytotoxic T lymphocyte
CTL, cytotoxic T cell Immunology A subset of T cells with a CD8 receptor on the surface that recognizes and lyses malignant or virally-infected self cells bearing self, ie 'haplotype restricted', class I MHC molecules. See Helper cells, Perforin, Suppressor cells.


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When white blood cells known as cytotoxic T lymphocytes (CTLs) spot certain combinations of HLA molecules and viral epitopes, they attack the infected cells.
We have generated promising preclinical data with our Hsp-influenza fusion protein candidate, which utilizes the highly conserved internal protein, NP, or nucleoprotein, to elicit a targeted cytotoxic T lymphocyte response against several flu strains.
 
 
 
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